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Chemistry: Recent submissions
Now showing items 321-340 of 964
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Protein-Protein Interactions Regulate Iron Homeostasis in Pseudomonas aeruginosa
(University of Kansas, 2015-08-31)Our lab had previously shown that the interaction between bacterioferritin (BfrB) and its associated ferredoxin (Bfd) enables mobilization of iron stored in BfrB. My research was aimed at understanding the mechanism of the ... -
Analytical Development and Characterization of the Metal-binding claMP Tag for Generation of Inline Bioconjugates to Enable Targeted Metal Delivery: Evaluation of Tag Placement, Metal Insertion and Retention, and Stability of Ni(II)-claMP-Tagged Protein Variants
(University of Kansas, 2014-08-31)Metal-based protein conjugates have become the primary means of achieving site- specific delivery of metal ions for use in clinical applications. Small, organic chelators are the primary entities used for metal delivery, ... -
Methods for Sultam Library Synthesis: One-pot, Sequential Protocols
(University of Kansas, 2014-08-31)The focus of this dissertation is to utilize vinyl sulfonamides in a series of reaction protocols towards the synthesis of sultam molecules by exploiting several salient features inherent to sulfonamides, including (i) ... -
Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
(American Chemical Society, 2009-09)The extensive glycosylation of HIV-1 envelope proteins (Env), gp120/gp41, is known to play an important role in evasion of host immune response by masking key neutralization epitopes and presenting the Env glycosylation ... -
Characterization of Host-Cell Line Specific Glycosylation Profiles of Early Transmitted/Founder HIV-1 gp120 Envelope Proteins
(American Chemical Society, 2013-03-01)Glycosylation plays an essential role in regulating protein function by modulating biological, structural, and therapeutic properties. However, due to its inherent heterogeneity and diversity, the comprehensive analysis ... -
Analysis of the disulfide bond arrangement of the HIV envelope protein CON-S gp140 ΔCFI shows variability in the V1 and V2 regions
(American Chemical Society, 2011-02-04)Disulfide bonding of cysteines is one of the most important protein modifications, and it plays a key role in establishing/maintaining protein structures in biologically active forms. Therefore, the determination of disulfide ... -
Two-photon absorption spectroscopy of stilbene and phenanthrene: Excited-state analysis and comparison with ethylene and toluene
(AIP Publishing, 2017-05-01)Two-photon absorption (2PA) spectra of several prototypical molecules (ethylene, toluene, trans- and cis-stilbene, and phenanthrene) are computed using the equation-of-motion coupled-cluster method with single and double ... -
Two-photon absorption spectroscopy of trans-stilbene, cis-stilbene, and phenanthrene: Theory and experiment
(AIP Publishing, 2017-04-11)Two-photon absorption (2PA) spectroscopy provides complementary, and sometimes more detailed, information about the electronic structure of a molecule relative to one-photon absorption (1PA) spectroscopy. However, our ... -
Orientation of Fluorescent Lipid Analog BODIPY-PC to Probe Lipid Membrane Properties: Insights from Molecular Dynamics Simulations
(American Chemical Society, 2011-05-19)Single-molecule fluorescence measurements have been used to characterize membrane properties, and recently showed a linear evolution of the fluorescent lipid analog BODIPY-PC towards small tilt angles in Langmuir-Blodgett ... -
Ganglioside Influence on Phospholipid Films Investigated with Single Molecule Fluorescence Measurements
(American Chemical Society, 2013-07-03)Single molecule fluorescence measurements are used to probe the effects of GM1 in DPPC monolayers. Langmuir-Blodgett films of GM1 and DPPC were doped with ~10−8 mol% of the fluorescent lipid probe, BODIPY-PC, and transferred ... -
Immobilization on a Nanomagnetic Co/C Surface Using ROM Polymerization: Generation of a Hybrid Material as Support for a Recyclable Palladium Catalyst
(Wiley, 2010-12-21)A novel hybrid material is reported as support for a recyclable palladium catalyst via surface immobilization of a ligand onto Co-based magnetic nanoparticles (NPs). A standard “click” reaction is utilized to covalently ... -
FRET-FCS Detection of Intra-Lobe Dynamics in Calmodulin
(American Chemical Society, 2011-07-28)Fluorescence correlation spectroscopy (FCS) can be coupled with Förster resonance energy transfer (FRET) to detect intramolecular dynamics of proteins on the microsecond time scale. Here we describe application of FRET-FCS ... -
Detecting Intramolecular Dynamics and Multiple FRET States by Fluorescence Correlation Spectroscopy
(American Chemical Society, 2010-03-06)Fluorescence correlation spectroscopy (FCS) is a robust method for the detection of intramolecular dynamics in proteins but is also susceptible to interference from other dynamic processes such as triplet kinetics and ... -
Conformational Heterogeneity of a Leucine Enkephalin Analog in Aqueous Solution and SDS Micelles: Comparison of Time- Resolved FRET and Molecular Dynamics Simulations
(American Chemical Society, 2009-10-29)We have undertaken time-resolved Förster resonance energy transfer (FRET) and molecular dynamics simulations to analyze conformations and conformational heterogeneity of an analog of leucine enkephalin in solution and in ... -
Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase
(ACS, 2015-03-13)The flavivirus nonstructural protein 3 (NS3) is a protease and helicase, and on the basis of its similarity to its homologue encoded by the hepatitis C virus (HCV), the flavivirus NS3 might be a promising drug target. Few ... -
Classic Maximum Entropy Recovery of the Average Joint Distribution of Apparent FRET Efficiency and Fluorescence Photons for Single-molecule Burst Measurements
(American Chemical Society, 2012-04-05)We describe a method for analysis of single-molecule Förster resonance energy transfer (FRET) burst measurements using classic maximum entropy. Classic maximum entropy determines the Bayesian inference for the joint ... -
Structural basis for the photoconversion of a phytochrome to the activated far-red light-absorbing form
(Nature Publishing Group, 2010-01-14)Phytochromes are a collection of bilin-containing photoreceptors that regulate numerous photoresponses in plants and microorganisms through their ability to photointerconvert between a red light-absorbing, ground state Pr ... -
Some iodine derivatives of hydroxy-diphenyl ether and related compounds
(University of Kansas, 1931) -
Two Distinct Ferritin-like Molecules in Pseudomonas aeruginosa: The Product of the bfrA Gene Is a Bacterial Ferritin (FtnA) and Not a Bacterioferritin (Bfr)
(ACS, 2011-06-14)Two distinct types of ferritin-like molecules often coexist in bacteria, the heme binding bacterioferritins (Bfr) and the non-heme binding bacterial ferritins (Ftn). The early isolation of a ferritin-like molecule from ... -
Concerted Motions Networking Pores and Distant Ferroxidase Centers Enable Bacterioferritin Function and Iron Traffic
(ACS, 2015-03-03)X-ray crystallography, molecular dynamics (MD) simulations and biochemistry were utilized to investigate the effect of introducing hydrophobic interactions in the 4-fold (N148L and Q151L) and B-pores (D34F) of Pseudomonas ...