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Chemistry: Recent submissions
Now showing items 301-320 of 964
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Design, Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1, 2, 3, 4- tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline Scaffolds
(American Chemical Society, 2010-11)The 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) ... -
A One-Pot, 3 Component, Domino Heck-aza-Michael Approach to Libraries of Functionalized 1, 1-Dioxido-1, 2-benzisothiazoline-2-acetic acids
(American Chemical Society, 2009)A sequential three-component synthesis of functionalized benzisothiazoline-3-acetic acid 1,1- dioxides utilizing a domino Heck-aza-Michael pathway is reported. This one-pot procedure rapidly assembles functionalized ... -
A review of microdialysis coupled to microchip electrophoresis for monitoring biological events
(Elsevier, 2015-02-20)Microdialysis is a powerful sampling technique that enables monitoring of dynamic processes in vitro and in vivo. The combination of microdialysis with chromatographic or electrophoretic methods yields along with selective ... -
Dysregulation of Intracellular Dopamine Stores Revealed in the R6/2 Mouse Striatum
(Wiley, 2010-02)Huntington’s disease is a fatal, neurodegenerative movement disorder characterized by preferential and extensive striatal degeneration. Here, we used fast-scan cyclic voltammetry to study the mobilization and efflux of ... -
Advances and Applications of Capillary Electrophoresis-Mass Spectrometry
(University of Kansas, 2016-12-31)Capillary electrophoresis-mass spectrometry (CE-MS) is a useful analytical technique capable of high efficiency separations from complex and low volume samples. However, the interface between CE and MS is not nearly as ... -
Redox Amination of Isatins
(University of Kansas, 2016-08-31)This thesis details the development for the synthesis of oxindoles containing an N1-C3 bisindole linkage while simultaneously oxidizing an indoline to an indole. This bond is made via redox amination, meaning no external ... -
Oligosaccharyltransferase Inhibition Induces Senescence in RTK-Driven Tumor Cells
(Nature Publishing Group, 2016-12)Asparagine (N)-linked glycosylation is a protein modification critical for glycoprotein folding, stability, and cellular localization. To identify small molecules that inhibit new targets in this biosynthetic pathway, we ... -
Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif
(Elsevier, 2015-07-15)Optimization of the sulfonamide-based kappa opioid receptor (KOR) antagonist probe molecule ML140 through constraint of the sulfonamide nitrogen within a tetrahydroisoquinoline moiety afforded a marked increase in potency. ... -
Indirect detection of superoxide in RAW 264.7 macrophage cells using microchip electrophoresis coupled to laser-induced fluorescence
(Springer Verlag, 2015-09)Superoxide is a naturally produced reactive oxygen species (ROS) in the human body and is involved in many pathological and physiological signaling processes. However, if superoxide formation is left unregulated, overproduction ... -
Microdialysis Sampling Coupled to Microchip Electrophoresis with Integrated Amperometric Detection on an All Glass Substrate
(Wiley, 2013-07-22)The development of an all-glass separation-based sensor using microdialysis coupled to microchip electrophoresis with amperometric detection is described. The system includes a flow-gated interface to inject discrete sample ... -
Phosphate Tether-Mediated Ring-Closing Metathesis Studies to Complex 1,3-anti-Diol-Containing Subunits
(Wiley, 2013-06-17)An array of examples of diastereoselective, phosphate tether-mediated ring-closing metathesis reactions, which highlight the importance of product ring size and substrate stereochemical compatibility, as well as complexity, ... -
Transition Metal-Catalyzed Decarboxylative Allylation and Benzylation Reactions
(ACS, 2011-03-09)A review. Transition metal catalyzed decarboxylative allylations, benzylations, and interceptive allylations are reviewed. -
Improving mass defect filters for human proteins
(American Chemical Society, 2010-10-01)The mass defect of a substance can be used in mass spectral analysis to identify peaks as likely belonging to a compound class, such as peptides, if the mass defect is within the known range for that compound class. For ... -
Reconstruction of Calmodulin Single-Molecule FRET States, Dye-Interactions, and CaMKII Peptide Binding by MultiNest and Classic Maximum Entropy
(Elsevier, 2013-08-30)We analyze single molecule FRET burst measurements using Bayesian nested sampling. The MultiNest algorithm produces accurate FRET efficiency distributions from single-molecule data. FRET efficiency distributions recovered ... -
Hyperglycemia Alters the Schwann Cell Mitochondrial Proteome and Decreases Coupled Respiration in the Absence of Superoxide Production
(American Chemical Society, 2010-01)Hyperglycemia-induced mitochondrial dysfunction contributes to sensory neuron pathology in diabetic neuropathy. Although Schwann cells (SCs) also undergo substantial degeneration in diabetic neuropathy, the effect of ... -
Encapsulation and selective recognition of sulfate anion in an azamacrocycle in water
(Royal Society of Chemistry, 2010-09-07)Structural characterization of a sulfate complex with an azamacrocycle suggests that one sulfate is encapsulated in the macrocyclic cavity with eight hydrogen bonds; a significant selectivity of the host was observed for ... -
Advances in Palladium-Catalyzed Allylation, Propargylation, and 1,3-Dienylation of Acetonitrile Pronucleophiles
(University of Kansas, 2016-08-31)Presented herein is the development and application of palladium-catalyzed methods for allylation, propargylation and 1,3-dienylation of acetonitrile pronucleophiles. The developed methods focus on optimizing both atom- ... -
Fabrication and Manipulation of Metallic Nanofeatures and CVD Graphene through Nanopatterning and Templating
(University of Kansas, 2014-08-31)Nanotechnology holds exciting potential to significantly advance research in many fields such as sensors, environmental sustainability and cleanup, energy harvesting and storage, as well as nanoelectronics. The resulting ... -
Controlling the Cycloreversion Reaction of a Diarylethene Derivative Using Sequential Two-Photon Excitation
(University of Kansas, 2014-08-31)Diarylethenes (DAE) are a class of photochromic molecular switches that convert between two structural isomers upon excitation with light. A great deal of research has been dedicated to elucidating the mechanisms of the ...