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    Design, Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1, 2, 3, 4- tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline Scaffolds

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    Lushington_2010.pdf (1.230Mb)
    Issue Date
    2010-11
    Author
    Dou, Dengfeng
    Viwanathan, Prasanth
    Li, Yi
    He, Guijia
    Alliston, Kevin R.
    Lushington, Gerald H.
    Brown-Clay, Joshua D.
    Padmanabhan, Radhakrishnan
    Groutas, William C.
    Publisher
    American Chemical Society
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    Copyright © American Chemical Society
    Metadata
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    Abstract
    The 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have lead to the identification of a WNV protease inhibitor (a 1-oxo-1, 2-dihydroisoquinoline-based derivative, 12j) which could potentially serve as a launching pad for a hit-to-lead optimization campaign. The identified hit was devoid of any inhibitory activity toward a panel of mammalian serine proteases.
    Description
    This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc100091h.
    URI
    http://hdl.handle.net/1808/24258
    DOI
    https://doi.org/10.1021/cc100091h
    Collections
    • Chemistry Scholarly Works [601]
    Citation
    Dou, D., Viwanathan, P., Li, Y., He, G., Alliston, K. R., Lushington, G. H., … Groutas, W. C. (2010). Design, Synthesis and In Vitro Evaluation of Potential West Nile Virus Protease Inhibitors Based on the 1-Oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline Scaffolds. Journal of Combinatorial Chemistry, 12(6), 836–843. http://doi.org/10.1021/cc100091h

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    KU Libraries
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    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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