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Bioengineering Program Scholarly Works: Recent submissions
Now showing items 121-140 of 154
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Mitotic and antiapoptotic effects of nanoparticles coencapsulating human VEGF and human angiopoietin-1 on vascular endothelial cells
(Dove Medical Press, 2011-05-24)Research towards the application of nanoparticles as carrier vehicles for the delivery of therapeutic agents is increasingly gaining importance. The angiogenic growth factors, human vascular endothelial growth factor (VEGF) ... -
Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters
(Public Library of Science, 2013-03-12)The beneficial effect of a microencapsulated feruloyl esterase producing Lactobacillus fermentum ATCC 11976 formulation for use in non-alcoholic fatty liver disease (NAFLD) was investigated. For which Bio F1B Golden Syrian ... -
Recent Advances in Application of Biosensors in Tissue Engineering
(Hindawi Publishing Corporation, 2014)Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications ... -
Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer: Preparation and In Vitro Assessment
(Hindawi Publishing Corporation, 2012)Most anticancer drugs are greatly limited by the serious side effects that they cause. Doxorubicin (DOX) is an antineoplastic agent, commonly used against breast cancer. However, it may lead to irreversible cardiotoxicity, ... -
Bone Marrow Stem Cell Derived Paracrine Factors for Regenerative Medicine: Current Perspectives and Therapeutic Potential
(Hindawi Publishing Corporation, 2011)During the past several years, there has been intense research in the field of bone marrow-derived stem cell (BMSC) therapy to facilitate its translation into clinical setting. Although a lot has been accomplished, plenty ... -
BacMam Virus Transduced Cardiomyoblasts Can Be Used for Myocardial Transplantation Using AP-PEG-A Microcapsules: Molecular Cloning, Preparation, and In Vitro Analysis
(Hindawi Publishing Corporation, 2010)The potential of genetically modified cardiomyoblasts in treating damaged myocardium is well known. However, efficient delivery of these cells is of major concern during treatment. The limiting factors are the massive cell ... -
Codelivery of antigen and an immune cell adhesion inhibitor is necessary for efficacy of soluble antigen arrays in experimental autoimmune encephalomyelitis
(Nature Publishing Group, 2014-04)Autoimmune diseases such as multiple sclerosis (MS) are typified by the misrecognition of self-antigen and the clonal expansion of autoreactive T cells. Antigen-specific immunotherapies (antigen-SITs) have long been explored ... -
Chondrogenic differentiation of stem cells in human umbilical cord stroma with PGA and PLLA scaffolds
(Scientific Research Publishing, 2015)The stem cells in the umbilical cord stroma, or Wharton's jelly, are referred to as human umbilical cord mesenchymal stromal cells (hUCMSCs) and have been shown to differentiate along a chondrogenic lineage. The aim of ... -
Decellularized Cartilage May Be a Chondroinductive Material for Osteochondral Tissue Engineering
(Public Library of Science, 2015-05-12)Extracellular matrix (ECM)-based materials are attractive for regenerative medicine in their ability to potentially aid in stem cell recruitment, infiltration, and differentiation without added biological factors. In ... -
Degradation of MEPE, DMP1, and Release of SIBLING ASARM-Peptides (Minhibins): ASARM-Peptide(s) Are Directly Responsible for Defective Mineralization in HYP
(Endocrine Society, 2008)Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and DMP1 (dentin matrix protein 1) result in X-linked hypophosphatemic rickets (HYP) and autosomal-recessive hypophospha ... -
Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells
(LumiText Publishing, 2010-09-09)The therapeutic usefulness of anticancer agents relies on their ability to exert maximal toxicity to cancer cells and minimal toxicity to normal cells. The difference between these two parameters defines the therapeutic ... -
Lymphatic trafficking kinetics and near-infrared imaging using star polymer architectures with controlled anionic character
(Elsevier, 2012-04-22)Targeted lymphatic delivery of nanoparticles for drug delivery and imaging is primarily dependent on size and charge. Prior studies have observed increased lymphatic uptake and retentions of over 48 hrs for negatively ... -
Laser enhanced high-intensity focused ultrasound thrombolysis: An in vitro study
(Acoustical Society of America, 2013-01-17)Laser-enhanced thrombolysis by high intensity focused ultrasound (HIFU) treatment was studied in vitro with bovine blood clots. To achieve laser-enhanced thrombolysis, laser light was employed to illuminate the sample ... -
Tensile strength of a surgeon’s or a square knot
(Elsevier, 2014-09-19)Objective—To test the integrity of surgeon’s knots and flat square knots using four different suture materials. Study Design—Chromic catgut, polyglactin 910, silk, and polydioxanone sutures were tied in the two types of ... -
Effect of the Degenerative State of the Intervertebral Disk on the Impact Characteristics of Human Spine Segments
(Frontiers, 2013-11-01)Models of the dynamic response of the lumbar spine have been used to examine vertebral fractures (VFx) during falls and whole body vibration transmission in the occupational setting. Although understanding the viscoelastic ... -
In vivo photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma using a near-infrared caspase-9 probe
(Society of Photo-optical Instrumentation Engineers, 2011-10-27)Anti-cancer drugs typically exert their pharmacological effect on tumors by inducing apoptosis, or programmed cell death, within the cancer cells. However, no tools exist in the clinic for detecting apoptosis in real time. ... -
A Review of Gene Delivery and Stem Cell Based Therapies for Regenerating Inner Ear Hair Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2011-09-13)Sensory neural hearing loss and vestibular dysfunction have become the most common forms of sensory defects, affecting millions of people worldwide. Developing effective therapies to restore hearing loss is challenging, ... -
Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance
(Society of Photo-optical Instrumentation Engineers, 2013-02)Radiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents ... -
Computational Knee Ligament Modeling Using Experimentally Determined Zero-Load Lengths
(Bentham Open, 2012-04-01)This study presents a subject-specific method of determining the zero-load lengths of the cruciate and collateral ligaments in computational knee modeling. Three cadaver knees were tested in a dynamic knee simulator. The ... -
Pharmacokinetic Evaluation of a DSPE-PEG2000 Micellar Formulation of Ridaforolimus in Rat
(MDPI, 2012-12-27)The rapamycin analog, ridaforolimus, has demonstrated potent anti-proliferative effects in cancer treatment, and it currently is being evaluated in a range of clinical cancer studies. Ridaforolimus is an extremely lipophilic ...