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    Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance

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    RenShenqiang_et_al_Photoacoustic.pdf (3.462Mb)
    Issue Date
    2013-02
    Author
    Zhang, Ti
    Cui, Huizhong
    Fang, Chia-Yi
    Su, Long-Jyun
    Ren, Shenqiang
    Chang, Huan-Cheng
    Yang, Xinmai
    Forrest, M. Laird
    Publisher
    Society of Photo-optical Instrumentation Engineers
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    Radiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents have been limited to quantum dots and gold particles, since most existing carbon-based nanoparticles, including fluorescent nanodiamonds, do not have sufficient optical absorption in the near-infrared (NIR) range. A new DND by He+ ion beam irradiation with very high NIR absorption was synthesized. These DNDs produced a 71-fold higher PA signal on a molar basis than similarly dimensioned gold nanorods, and 7.1 fmol of DNDs injected into rodents could be clearly imaged 3 mm below the skin surface with PA signal enhancement of 567% using an 820-nm laser wavelength.
    Description
    This is the publisher's version, also available electronically from http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1619539
    URI
    http://hdl.handle.net/1808/14490
    DOI
    https://doi.org/10.1117/1.JBO.18.2.026018
    ISSN
    1083-3668
    Collections
    • Bioengineering Program Scholarly Works [144]
    • Chemistry Scholarly Works [610]
    • Mechanical Engineering Scholarly Works [135]
    Citation
    Ti Zhang et al. (2013). Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance. Journal of Biomedical Optics 18(2). http://www.dx.doi.org/10.1117/1.JBO.18.2.026018

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    KU Libraries
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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