Bioengineering Program Scholarly Works
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In-plane Extended Nano-coulter Counter (XnCC) for the Label-free Electrical Detection of Biological Particles
(Wiley, 2022-06-14)We report an in-plane extended nanopore Coulter counter (XnCC) chip fabricated in a thermoplastic via imprinting. The fabrication of the sensor utilized both photolithography and focused ion beam milling to make the ... -
Subthreshold white noise vibration alters trembling sway in older adults
(Elsevier, 2023-06-28)Background Somatosensory deficit is a significant contributor to falls in older adults. Stochastic resonance has shown promise in recent studies of somatosensation-based balance disorders, improving many measures of ... -
Design considerations for piezocomposite materials for electrical stimulation in medical implants
(Taylor and Francis Group, 2022)Incidence of non-union following long bone fracture fixation and spinal fusion procedures is increasing, and very costly for patients and the medical system. Direct current (DC) electrical stimulation has shown success as ... -
Post-ischemic reorganization of sensory responses in cerebral cortex
(Frontiers Media, 2023-06-02)Introduction: Sensorimotor integration is critical for generating skilled, volitional movements. While stroke tends to impact motor function, there are also often associated sensory deficits that contribute to overall ... -
Tailoring the secretome composition of mesenchymal stem cells to augment specific functions of epidermal regeneration: an in vitro diabetic model
(Frontiers Media, 2023-06-12)Introduction: Wound healing consists of a dynamic series of events that are highly dependent on paracrine factors for proper progression through the phases of wound healing. Inappropriate progression through the phases is ... -
Quality control in resting-state fMRI: the benefits of visual inspection
(Frontiers Media, 2023-05-04)Background: A variety of quality control (QC) approaches are employed in resting-state functional magnetic resonance imaging (rs-fMRI) to determine data quality and ultimately inclusion or exclusion of a fMRI data set in ... -
Engineering peptide-polymer hybrids for targeted repair and protection of cervical lesions
(Frontiers Media, 2022-11-25)By 2060, nearly 100 million people in the U.S. will be over age 65 years. One-third of these older adults will have root caries, and nearly 80% will have dental erosion. These conditions can cause pain and loss of tooth ... -
Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization
(MDPI, 2023-03-28)Overcoming the short lifespan of current dental adhesives remains a significant clinical need. Adhesives rely on formation of the hybrid layer to adhere to dentin and penetrate within collagen fibrils. However, the ability ... -
Autonomous-Strengthening Adhesive Provides Hydrolysis-Resistance and Enhanced Mechanical Properties in Wet Conditions
(MDPI, 2022-08-27)The low-viscosity adhesive that is used to bond composite restorative materials to the tooth is readily damaged by acids, enzymes, and oral fluids. Bacteria infiltrate the resulting gaps at the composite/tooth interface, ... -
Silica-Coated Magnetic Nanoparticles for Vancomycin Conjugation
(American Chemical Society, 2022-08-16)Drug resistance is a global health challenge with thousands of deaths annually caused by bacterial multidrug resistance (MDR). Efforts to develop new antibacterial molecules do not meet the mounting needs imposed by the ... -
CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia
(Frontiers Media, 2022-10-04)We applied quantitative CT image matching to assess the degree of motion in the idiopathic ILD such as usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Twenty-one normal subjects and 42 ... -
Novel hydrogel system eliminates subculturing and improves retention of nonsenescent mesenchymal stem cell populations
(Future Science Group, 2022-10-12)Aim: To compare the physiological behavior of mesenchymal stem/stromal cells (MSCs) within an expandable tissue-mimetic 3D system relative to in vitro expansion in a traditional 2D system. Methods: Adipose-derived MSCs ... -
The feasibility of ultrasound-assisted endovascular laser thrombolysis in an acute rabbit thrombosis model
(Wiley, 2021-07-02)Purpose This study aimed to test the feasibility of combined ultrasound and laser technique, namely, ultrasound-assisted endovascular laser thrombolysis (USELT), for thrombolysis by conducting in vivo tests in a rabbit ... -
Fluidic operation of a polymer-based nanosensor chip for analysing single molecules
(Cambridge University Press, 2022-06-27)Most medical diagnostic tests are expensive, involve slow turnaround times from centralized laboratories and require highly specialized equipment with seasoned technicians to carry out the assay. To facilitate realization ... -
Effect of Photo-Mediated Ultrasound Therapy on Nitric Oxide and Prostacyclin from Endothelial Cells
(National Academy of Sciences, 2022-03-03)Several studies have investigated the effect of photo-mediated ultrasound therapy (PUT) on the treatment of neovascularization. This study explores the impact of PUT on the release of the vasoactive agents nitric oxide ... -
Estrogen Signaling Dictates Musculoskeletal Stem Cell Behavior: Sex Differences in Tissue Repair
(Mary Ann Liebert, 2022-08-08)Sexual dimorphisms in humans and other species exist in visually evident features such as body size and less apparent characteristics, including disease prevalence. Current research is adding to a growing understanding of ... -
Activity dependent stimulation increases synaptic efficacy in spared pathways in an anesthetized rat model of spinal cord contusion injury
(IOS Press, 2022-04-08)Background: Closed-loop neuromodulation systems have received increased attention in recent years as potential therapeutic approaches for treating neurological injury and disease. Objective: The purpose of this study ... -
Antimicrobial Peptide–Polymer Conjugates for Dentistry
(American Chemical Society, 2020-03-13)Bacterial adhesion and growth at the composite/adhesive/tooth interface remain the primary cause of dental composite restoration failure. Early colonizers, including Streptococcus mutans, play a critical role in the formation ... -
A brain-spinal interface (BSI) system-on-chip (SoC) for closed-loop cortically-controlled intraspinal microstimulation
(Springer, 2018-01-17)This paper reports on a fully miniaturized brain-spinal interface system for closed-loop cortically-controlled intraspinal microstimulation (ISMS). Fabricated in AMS 0.35 µm two-poly four-metal complementary metal–oxide– ... -
Self-Assembled Recombinant Proteins on Metallic Nanoparticles as Bimodal Imaging Probes
(SAGE Publications, 2019-01-23)Combining multiple modalities is central to developing the new methods for sensing and imaging that are required for comprehensive understanding of events at the molecular level. Various imaging modalities have been developed ...
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