Bioengineering Program Scholarly Works
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Recent Submissions
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Engineering peptide-polymer hybrids for targeted repair and protection of cervical lesions
(Frontiers Media, 2022-11-25)By 2060, nearly 100 million people in the U.S. will be over age 65 years. One-third of these older adults will have root caries, and nearly 80% will have dental erosion. These conditions can cause pain and loss of tooth ... -
Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization
(MDPI, 2023-03-28)Overcoming the short lifespan of current dental adhesives remains a significant clinical need. Adhesives rely on formation of the hybrid layer to adhere to dentin and penetrate within collagen fibrils. However, the ability ... -
Autonomous-Strengthening Adhesive Provides Hydrolysis-Resistance and Enhanced Mechanical Properties in Wet Conditions
(MDPI, 2022-08-27)The low-viscosity adhesive that is used to bond composite restorative materials to the tooth is readily damaged by acids, enzymes, and oral fluids. Bacteria infiltrate the resulting gaps at the composite/tooth interface, ... -
Silica-Coated Magnetic Nanoparticles for Vancomycin Conjugation
(American Chemical Society, 2022-08-16)Drug resistance is a global health challenge with thousands of deaths annually caused by bacterial multidrug resistance (MDR). Efforts to develop new antibacterial molecules do not meet the mounting needs imposed by the ... -
CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia
(Frontiers Media, 2022-10-04)We applied quantitative CT image matching to assess the degree of motion in the idiopathic ILD such as usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Twenty-one normal subjects and 42 ... -
Novel hydrogel system eliminates subculturing and improves retention of nonsenescent mesenchymal stem cell populations
(Future Science Group, 2022-10-12)Aim: To compare the physiological behavior of mesenchymal stem/stromal cells (MSCs) within an expandable tissue-mimetic 3D system relative to in vitro expansion in a traditional 2D system. Methods: Adipose-derived MSCs ... -
The feasibility of ultrasound-assisted endovascular laser thrombolysis in an acute rabbit thrombosis model
(Wiley, 2021-07-02)Purpose This study aimed to test the feasibility of combined ultrasound and laser technique, namely, ultrasound-assisted endovascular laser thrombolysis (USELT), for thrombolysis by conducting in vivo tests in a rabbit ... -
Fluidic operation of a polymer-based nanosensor chip for analysing single molecules
(Cambridge University Press, 2022-06-27)Most medical diagnostic tests are expensive, involve slow turnaround times from centralized laboratories and require highly specialized equipment with seasoned technicians to carry out the assay. To facilitate realization ... -
Effect of Photo-Mediated Ultrasound Therapy on Nitric Oxide and Prostacyclin from Endothelial Cells
(National Academy of Sciences, 2022-03-03)Several studies have investigated the effect of photo-mediated ultrasound therapy (PUT) on the treatment of neovascularization. This study explores the impact of PUT on the release of the vasoactive agents nitric oxide ... -
Estrogen Signaling Dictates Musculoskeletal Stem Cell Behavior: Sex Differences in Tissue Repair
(Mary Ann Liebert, 2022-08-08)Sexual dimorphisms in humans and other species exist in visually evident features such as body size and less apparent characteristics, including disease prevalence. Current research is adding to a growing understanding of ... -
Activity dependent stimulation increases synaptic efficacy in spared pathways in an anesthetized rat model of spinal cord contusion injury
(IOS Press, 2022-04-08)Background: Closed-loop neuromodulation systems have received increased attention in recent years as potential therapeutic approaches for treating neurological injury and disease. Objective: The purpose of this study ... -
Antimicrobial Peptide–Polymer Conjugates for Dentistry
(American Chemical Society, 2020-03-13)Bacterial adhesion and growth at the composite/adhesive/tooth interface remain the primary cause of dental composite restoration failure. Early colonizers, including Streptococcus mutans, play a critical role in the formation ... -
A brain-spinal interface (BSI) system-on-chip (SoC) for closed-loop cortically-controlled intraspinal microstimulation
(Springer, 2018-01-17)This paper reports on a fully miniaturized brain-spinal interface system for closed-loop cortically-controlled intraspinal microstimulation (ISMS). Fabricated in AMS 0.35 µm two-poly four-metal complementary metal–oxide– ... -
Self-Assembled Recombinant Proteins on Metallic Nanoparticles as Bimodal Imaging Probes
(SAGE Publications, 2019-01-23)Combining multiple modalities is central to developing the new methods for sensing and imaging that are required for comprehensive understanding of events at the molecular level. Various imaging modalities have been developed ... -
Photo-Mediated Ultrasound Therapy for the Treatment of Corneal Neovascularization in Rabbit Eyes
(Association for Research in Vision and Ophthalmology, 2020-12-09)Purpose: Corneal neovascularization (CNV) is the invasion of new blood vessels into the avascular cornea, leading to reduced corneal transparency and visual acuity, impaired vision, and even blindness. Current treatment ... -
Combining genetic algorithm with machine learning strategies for designing potent antimicrobial peptides
(BMC, 2021-05-11)Background Current methods in machine learning provide approaches for solving challenging, multiple constraint design problems. While deep learning and related neural networking methods have state-of-the-art performance, ... -
Reconfigurable Dual Peptide Tethered Polymer System Offers a Synergistic Solution for Next Generation Dental Adhesives
(MDPI, 2021-06-18)Resin-based composite materials have been widely used in restorative dental materials due to their aesthetic, mechanical, and physical properties. However, they still encounter clinical shortcomings mainly due to recurrent ... -
Ultra-high-resolution computed tomography shows changes in the lungs related with airway hyperresponsiveness in a murine asthma model
(Nature Research, 2021-09-02)In vivo presentation of airway hyper-responsiveness (AHR) at the different time points of the allergic reaction is not clearly understood. The purpose of this study was to investigate how AHR manifests in the airway and ... -
Self-assembling antimicrobial peptides on nanotubular titanium surfaces coated with calcium phosphate for local therapy
(Elsevier, 2018-09-12)Bacterial infection is a serious medical problem leading to implant failure. The current antibiotic based therapies rise concerns due to bacterial resistance. The family of antimicrobial peptides (AMP) is one of the promising ... -
Coordination of trunk and foot acceleration during gait is affected by walking velocity and fall history in elderly adults
(Elsevier, 2018-09-07)Background: Falling is a significant concern for many elderly adults but identifying individuals at risk of falling is difficult, and it is not clear how elderly adults adapt to challenging walking. Aims: The aim of ...
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