Molecular Biosciences Dissertations and Theses: Recent submissions
Now showing items 61-80 of 270
-
IDENTIFICATION OF THE RNA BINDING PROTEIN RBM3 AS A NOVEL EFFECTOR OF β-CATENIN SIGNALING AND COLON CANCER STEM CELLS
(University of Kansas, 2014-05-31)The intestinal epithelium is one of the fastest renewing tissues within the adult. This renewal is primarily driven by the intestinal epithelial stem cell compartment and homeostasis of this compartment needs to be strictly ... -
A characterization of deficits associated with loss of NCB5OR in the mouse brain
(University of Kansas, 2016-05-31)The simplest approach to the study of an event is to first consider that of the simplest cause. When investigating the mechanisms governing idiopathic diseases, this generally takes the form of an ab initio genetic approach, ... -
PARACELLULAR EPITHELIAL TRANSPORT MAXIMIZES ENERGY EFFICIENCY IN THE KIDNEY
(University of Kansas, 2016-08-31)Claudins are tight junction transmembrane proteins that act as paracellular ion channels. The proximal renal tubule reabsorbs 70% of glomerulus-filtered Na+. Of this Na+, up to 1/3 is reabsorbed passively via the paracellular ... -
PROTEOSTASIS IN BUDDING YEAST
(University of Kansas, 2016-08-31)Cells utilize an array of quality control mechanisms to maintain a stable and functional proteome. These protein homeostasis mechanisms counteract the constant challenges of protein damages through an integrated network ... -
A genomic analysis of meiosis in Drosophila melanogaster
(University of Kansas, 2016-05-31)Meiosis is a specialized form of cell division in which a single diploid cell undergoes one round of genome duplication followed by two rounds of cell division to produce four haploid gametes. In most organisms, including ... -
SUMOylation at the centromere: The role of SUMOylation of the DNA topoisomerase IIα C-terminal domain in the regulation of mitotic kinases in cell cycle progression.
(University of Kansas, 2016-08-31)In many model systems, SUMOylation is required for proper mitosis; in particular, chromosome segregation during anaphase. It was previously shown that interruption of SUMOylation through the addition of the dominant negative ... -
NMR studies of molecular interactions involved in the type III secretion system, SUMOylation, and the RNA binding protein HuR
(University of Kansas, 2016-08-31)Proteins are one of the most intriguing, versatile, and complex macromolecules in living systems. Proteins rarely function independently and perform their activities through a multitude of interactions with other proteins ... -
New roles for Hox and Wnt in Cell Migration
(University of Kansas, 2016-08-31)Neuron migration is a critical process during central nervous system development. In the dissertation below I report new roles for established genes such as Wnt and Hox, and describe roles for several new genes in neuron ... -
THE COMPLEX GENETICS OF LIFESPAN AND XENOBIOTIC RESISTANCE IN DROSOPHILA MELANOGASTER
(University of Kansas, 2016-08-31)It is constantly observed that populations of species, like the DSPR, harbor considerable genetic variation for phenotypic traits. However, our understanding of the location, effect, and frequency of alleles that create ... -
Genetic Control of Tissue Specific Growth in the Drosophila Trachea
(University of Kansas, 2016-08-31)In most organisms, different tissues and organs grow at different rates relative to each other, suggesting underlying growth mechanisms that act tissue specifically. The mechanisms of tissue specific growth are less well ... -
Studies on Antioxidant induced giantism and cannibalism of the ciliated protozoan, Blepharisma americanum (Suzuki, 1954)
(University of Kansas, 1981) -
Some studies on the morphology of B. coli
(University of Kansas, 1929) -
INVESTIGATING THE PRESENCE OF MITOCHONDRIAL DNA METHYLATION, ITS ALTERATION AND ASSOCIATION WITH MITOCHONDRIAL TRANSCRIPTION AND MITOCHONDRIAL FUNCTION
(University of Kansas, 2015-12-31)Mitochondrial proteins are encoded by both the nuclear and mitochondrial genome (mtDNA). Thus, alterations in mtDNA affect mitochondrial function and are involved in a plethora of diseases associated with mitochondrial ... -
Ewsa-dependent regulation of Runx2 during zebrafish skeletogenesis
(University of Kansas, 2016-05-31)Ewing’s sarcoma is the second most common malignant bone cancer found in adolescents, and the genetic hallmark of this disease is the presence of the aberrant chimeric fusion protein EWS/FLI1. This fusion is induced by the ... -
Heterogeneity and Decision-Making in Cellular Signaling Networks
(University of Kansas, 2016-05-31)Signaling networks are the means by which cells adapt to their environment. Over the last decade, cellular decision-making has been shown to exist in the midst of substantial heterogeneity, even among isogenic cells. The ... -
SUMOylation in centromere organization: Regulation of a putative chromatin remodeler, Polo-like kinase 1 interacting checkpoint helicase (PICH) by mitotic SUMOylation
(University of Kansas, 2016-05-31)SUMOylation is a posttranslational modification that can mediate diverse cellular processes such as DNA replication, transcription, DNA repair, cell cycle regulation, signal transduction and cell death. Similar to ... -
ELUCIDATION OF THE NEEDLE-TIP AND TIP-TRANSLOCON INTERACTIONS OF THE SALMONELLA SPI-1 TYPE III SECRETION SYSTEM AND IDENTIFICATION OF SMALL MOLECULE BINDERS OF THE TIP AND TRANSLOCON PROTEINS
(University of Kansas, 2016-05-31)The type III secretion system (T3SS) is required by many pathogenic Gram-negative bacteria for the initiation and maintenance of infections within eukaryotic host cells. T3SS harboring bacteria include the causative agents ... -
Pocket optimization and its application to identify small-molecule inhibitors of protein-protein interactions
(University of Kansas, 2016-05-31)Because of their ubiquitous nature in many cellular processes, modulating protein-protein interactions offers tremendous therapeutic potential. However, protein-protein interactions remain a difficult class of drug targets, ... -
Role of Zinc in Parkin RING2 E3 Ubiquitin Ligase Ubiquitination
(University of Kansas, 2016-05-31)In common neurodegenerative diseases among older adults, Parkinson’s disease (PD) ranks the second after Alzheimer’s disease. Symptoms of Parkinson’s disease are shaking, slowness of movement, rigidity of the extremities ... -
Development of protein-protein docking methodology and benchmarking environment
(University of Kansas, 2016-05-31)Structural characterization of proteins is essential for understanding life processes at the molecular level. However, only a fraction of known proteins have experimentally determined structures. That fraction is even ...