Molecular Biosciences Dissertations and Theses: Recent submissions
Now showing items 221-240 of 270
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EXC-5 Controls Intracellular Trafficking in Order to Maintain the Apical Structure of the C. elegans Excretory Canal
(University of Kansas, 2011-04-26)The goal of this work is to understand how cells form and maintain tubular shapes. The protein EXC-5 is necessary for a small tubular structure in Caenorhabditis elegans to maintain its shape. C. elegans is a small, easily ... -
STRUCTURAL AND FUNCTIONAL STUDIES OF AN ATYPICAL OMPR/PHOB TRANSCRIPTIONAL REGULATOR, CHXR, FROM CHLAMYDIA TRACHOMATIS
(University of Kansas, 2011-04-18)Chlamydia infections have an immense impact on public health and are associated with diverse disease manifestations including atherosclerosis, blindness, and sterility. The chlamydial developmental cycle is intrinsically ... -
The specification and patterning of the Drosophila egg chamber
(University of Kansas, 2010-12-07)The generation of cell polarity through the localization of specific mRNAs and proteins to discrete subcellular sites is fundamental to asymmetric cell division, tissue morphogenesis, cell migration, and most other ... -
RNA Helicase 1 interacts with an ABCRNAi Transporter: Genetic Interactions with haf-6
(University of Kansas, 2010-12-03)The C. elegans rha-1 gene encodes a conserved helicase with ATP-dependent DEAD/H-box and double-stranded RNA binding domains. rha-1 is orthologous to the Drosophila maleless gene(MLE), an essential component of the dosage ... -
AN AXON'S JOURNEY TO FIND ITS PATH: IN VIVO CHARACTERIZATION OF THE MODULATORS AND EFFECTORS OF THE RAC GTPASE SIGNALING PATHWAY INVOLVED IN AXON GUIDANCE
(University of Kansas, 2011-04-11)The molecular mechanisms leading to axonal guidance are vital for the proper wiring of the nervous system. Many psychiatric disorders may arise from the improper development of the brain. If an axon does not form, or is ... -
WATCHING NEURONS GROW: GUIDANCE RECEPTORS, SIGNAL TRANSDUCTION MACHINERY AND CYTOSKELETAL REGULATORS AFFECT GROWTH CONE MORPHOLOGY AND DYNAMICS IN C. ELEGANS
(University of Kansas, 2011-04-11)The growth cone of a developing axon senses and responds to extracellular cues resulting in the migration of the growth cone and thus the axon to the correct target in the nervous system. Growth cones display dynamic, ... -
Mitotic SUMOylation: from the mechanism to functions
(University of Kansas, 2010-08-10)ABSTRACT Protein modification by conjugation of SUMO molecules to target proteins is an essential process for both genomic stability and cell viability. In vertebrates, the SUMOylation process involves three SUMO paralogues, ... -
MECHANISMS OF MICROVASCULAR INFLAMMATION INDUCED BY ALVEOLAR HYPOXIA
(University of Kansas, 2010-08-23)Alveolar hypoxia is observed in a number of clinical settings, and is frequently associated with systemic effects, many of which present an inflammatory component. Reduction of alveolar PO2 in rats induces a rapid and ... -
The Role of the G-Protein Coupled Receptor C-C Chemokine Receptor 7 in T Lymphocyte Migration and Breast Cancer Metastasis
(University of Kansas, 2010-08-23)C-C Chemokine Receptor 7 (CCR7) promotes migration of T lymphocytes into and throughout lymph nodes via ligands CCL21 and CCL19. The mechanisms by which CCR7 directs T lymphocyte trafficking are unknown. Using migration ... -
A Role for Adiponectin in Trophoblast Function
(University of Kansas, 2010-07-28)As the ultimate mediator of fetal growth and well-being, the placenta is inundated with a number of molecular cues from both the maternal and fetal systems. Successful integration of these signals is critical to the ongoing ... -
Molecular analysis of mammalian adenylyl cyclases and edema factor, a bacterial adenylyly cyclase toxin
(University of Kansas, 2008-12-16)Adenylyl cyclases (ACs) catalyze the conversion of ATP to cAMP, an important second messenger central to many signaling pathways. Nine different isoforms of mammalian ACs (mACs) are present, each with distinct localization, ... -
CATALYSIS AND INHIBITION OF MYCOBACTERIUM TUBERCULOSIS METHIONINE AMINOPEPTIDASE
(University of Kansas, 2010-06-04)Tuberculosis, caused by Mycobacterium tuberculosis, is the leading cause of death due to infectious disease. Now, the prevalence of multidrug-resistant and extensively drug-resistant TB, and the emergence of co-infection ... -
Molecular Mechanism of Parvovirus Infection
(University of Kansas, 2010-06-25)The studies to be presented are composed of two parts: 1) investigating the molecular mechanisms underlying cytopathic effects induced during infections of parvovirus B19 (B19V) and minute virus of canines (MVC); 2) ... -
Biochemical and Developmental Characterization of a SNF2-like ATPase Amplified in Liver Cancer 1 (ALC1)
(University of Kansas, 2010-06-07)Post-translational modifications play a key role in recruiting chromatin remodeling and modifying enzymes to specific regions of chromosomes to modulate chromatin structure. Alc1 (Amplified in Liver Cancer 1), a member of ... -
Spatial Regulation of Cell Division by the Min System in E. coli
(University of Kansas, 2010-05-04)The E. coli Min system contributes to spatial regulation of cell division by preventing Z ring assembly at cell poles. Critical to our understanding of this spatial regulation by the Min system is the mechanism of action ... -
Regulation of sympathetic plasticity in the heart
(University of Kansas, 2009-09-02)Following myocardial infarction, elevated sympathetic neuronal sprouting at the infarct border region leads to hyperexcitability which increases the risk of arrhythmias and sudden cardiac death. Surviving individuals with ... -
Characterization of the roles of the Nck interacting kinase MIG-15 and the Rac GTPases in neuronal migration in Caenorhabditis elegans.
(University of Kansas, 2010-04-23)Neuronal migration is essential to the formation of the central nervous system in vertebrates. In Caenorhabditis elegans, a screen was performed previously to identify mutations that affected the migration of the Q neuroblast ... -
Forward and reverse genetic approaches to identify genes involved in leg morphogenesis in Drosophila
(University of Kansas, 2010-04-26)Development of Drosophila leg imaginal discs provides an ideal model to study hormone-regulated morphogenesis. During the onset of metamorphosis, a pulse of ecdysone triggers the rapid transformation of flat leg imaginal ... -
USE OF ANIMAL FREE COMPONENTS IN THE COMMERCIAL MANUFACTURE OF VETERINARY CLOSTRIDIAL ANTIGENS
(University of Kansas, 2010-04-21)The use of animal-origin components and media in the commercial production of clostridial antigens for veterinary vaccine manufacture constitutes an unnecessary and excessive risk to food safety and health. For over 70 ... -
Investigation of the Structure and Function of Type III Secretion Needle and Tip Proteins
(University of Kansas, 2009-04-22)Many Gram-negative pathogens possess type III secretion systems as part of their required virulence factor repertoire. The type III secretion apparatus (TTSA) spans the bacterial inner and outer membranes and resembles a ...