Molecular Biosciences Dissertations and Theses: Recent submissions
Now showing items 201-220 of 270
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Schistosoma Mansonii aspartic protease expression and refolding trials
(University of Kansas, 2011-12-31)Schistosomiasis is a parasitic disease that causes considerable socio-economic losses in affected areas due to loss of productive capacity of affected individuals and high rates of morbidity and mortality. Therapeutic ... -
Conformational Entropy in PEPCK Catalysis: Dynamic Motions Critical to Function
(University of Kansas, 2011-12-31)Enzymes increase the rate at which chemical reactions occur. How they achieve this rate increase has been an area of intense research for many years. Multiple studies have shown that dynamic motions of individual protein ... -
CHARACTERIZATION OF MATRIMONY'S ROLE AS A POLO KINASE REGULATOR DURING DROSOPHILA FEMALE MEIOSIS
(University of Kansas, 2011-12-31)Regulatory interactions that occur between Polo-like kinase 1 (Plk1) and its protein partners are critical for promoting many different cell division events. Indeed, Plk1 is found mis-regulated in a diverse set of human ... -
THE ROLE OF ADAPTOR PROTEIN GADS IN CD8+ T CELL-MEDIATED IMMUNITY
(University of Kansas, 2011-12-31)CD8+ T cells are the branch of the adaptive immune system responsible for recognizing and killing tumor cells or cells infected with intracellular pathogens, such as Listeria monocytogenes (LM). However, when CD8+ T cells ... -
Nigrostriatal Dopmaine Function and Insulin Resistance
(University of Kansas, 2011-08-31)Clinical studies have linked Type 2 Diabetes (T2D) with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD). Although the link between T2D and AD is relatively well established, the potential ... -
THE NA,K-ATPASE α4 ISOFORM: MECHANISMS OF ACTION, REGULATION AND RELEVANCE TO MALE FERTILITY
(University of Kansas, 2011-08-31)Ion movement across the plasma membrane is essential for the function of spermatozoa and defects in the mechanisms that drive ion transport between the environment and cell cytoplasm can affect male fertility. The active ... -
Some Studies in the Agglutination of Typhoid
(University of Kansas, 1911-05-15) -
Multiple Distinct Roles for the Rab11 GTPase in the Somatic Cells of the Drosophila Egg Chamber
(University of Kansas, 2011-05-31)The Drosophila egg chamber provides an excellent system in which to study the specification and differentiation of epithelial cell fates because all of the steps, starting with the division of the corresponding stem cells ... -
Modulation of Tau Dysfunction In Vitro
(University of Kansas, 2011-05-31)The microtubule associated protein tau is a causative factor in a class of neurodegenerative diseases termed tauopathies. Alzheimer's disease (AD) is the most prevalent tauopathy. In AD, natively unfolded, tau becomes ... -
CONSERVED VIRUS PROTEIN FAMILIES IN BACTERIOPHAGE GENOMES AND IN METAGENOMES OF HUMANS
(University of Kansas, 2011-08-31)Viruses are likely to be the most abundant genomes in the biosphere, displaying remarkable molecular diversity. Their fast-evolving genomes and lack of universal marker genes make phylogenetic and taxonomic studies more ... -
ASTROCYTE-ENDOTHELIAL INTERACTIONS: IMPLICATIONS FOR HIV-ASSOCIATED NEUROCOGNITIVE DISORDER
(University of Kansas, 2011-08-31)During the course of HIV-1 disease, virus neuroinvasion occurs as an early event, within weeks following infection. Intriguingly, subsequent central nervous system (CNS) complications manifest only decades after the initial ... -
Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
(University of Kansas, 2011-08-31)Colorectal cancer is the second leading cause of cancer related deaths in the United States. Approximately 80% of all colon cancers are associated with a mutation in the Adenomatous polyposis coli (APC) tumor suppressor ... -
MODELING PROTEIN INTERACTIONS THROUGH STRUCTURE ALIGNMENT
(University of Kansas, 2011-08-31)Rapid accumulation of the experimental data on protein-protein complexes drives the paradigm shift in protein docking from "traditional" template free approaches to template based techniques. Homology docking algorithms ... -
Interplay of chemical neurotransmitters regulates developmental increase in electrical synapses
(University of Kansas, 2011-08-31)Coupling of neurons by electrical synapses (gap junctions) transiently increases during embryonic and/or early postnatal development of the mammalian central nervous system and plays an important role in a number of ... -
Structure-function Study of PchB, an Isochorismate-Pyruvate Lyase from <italic>Pseudomonas aeruginosa</italic>
(University of Kansas, 2011-07-31)Enzymes act as biological catalysts for chemical reactions that would otherwise occur at rates insufficient for the survival and growth of an organism. Understanding the fundamental forces that drive catalysis in enzymes ... -
NMR Structural Studies of Type III Secretion System Tip Proteins
(University of Kansas, 2011-08-31)The type III secretion system (T3SS) is a complex set of regulatory and structural protein machinery common to many Gram-negative bacteria for virulence. Many of these bacterial species are human pathogens and cause a ... -
Surface Localization Determinants of Borrelia burgdorferi Lipoproteins
(University of Kansas, 2011-02-25)Borrelia spirochetes are the causative agents of Lyme disease and relapsing fever, two common vector-borne diseases. Early experimental evidence, gained from development of genetic tools in the Lyme disease spirochete, ... -
ESTROGEN RECEPTOR REGULATION OF GLUCOSE AND FAT METABOLISM IN THE SKELETAL MUSCLE AND ADIPOSE TISSUE
(University of Kansas, 2011-04-18)Clinical studies suggest that postmenopausal women are at an increased risk for type 2 diabetes (T2D), and hormone replacement therapy can ameliorate this risk. Considerable clinical and experimental evidence exists ... -
NMR STUDIES OF THE GLYCOPROTEIN CYTOPLASMIC TAILS OF HANTAVIRUS AND CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS
(University of Kansas, 2011-04-25)The Bunyaviridae family of viruses is a diverse grouping of approximately 350 members that is present throughout the world. Viruses range from the innocuous to the severely pathogenic and impact not only public health, but ... -
Yeast Chemical Genetics For Identifying Regulators of Late Secretory Traffic Pathways
(University of Kansas, 2011-04-25)Abstract The intracellular transport of proteins and membrane lipids to the cell surface or between organelles is a fundamental process in eukaryotic cells. This process is required for the biogenesis and maintenance of ...