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Molecular Biosciences: Recent submissions
Now showing items 861-880 of 887
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Cloning and characterization of exc-9, a Caenorhabditis elegans CRIP homologue that regulates tubular structure
(University of Kansas, 2007-10-12)Forming and maintaining tubular structure is fundamental to organismal development. The excretory canal cell of C.elegans forms a single-cell epithelial tubule, which provides a simple model for tubular structure study. ... -
The Biochemistry of Siderophore Biosynthesis
(University of Kansas, 2008-01-25)Pathogenic bacteria are becoming increasingly antibiotic resistant. For this reason, the development of novel antibiotics is extremely important. A potential new target for antimicrobial drugs is the production of siderophores. ... -
Studies of the C-terminal Region of the Gamma Subunit of the Chloroplast ATP Synthase
(University of Kansas, 2008-06-18)The C-terminal region of the γ subunit of the ATP synthase forms a "catch" with an anionic loop on one of the three β subunits within the catalytic αβ hexamer of the F1 segment. A series of single and multiple amino acid ... -
Bacillus subtilis Soj (ParA): The involvement of DNA binding and dynamic localization in plasmid partitioning
(University of Kansas, 2008-05-08)The ParA family of ATPases encompasses proteins with a wide variety of functions. The prototype of this family is the ParA ATPase from the P1 prophage plasmid, which, along with ParB and the parS binding site, is required ... -
Telomerase Regulation and Telomere Maintenance during Human T-cell Leukemia/Lymphoma Virus (HTLV-I) Transformation
(University of Kansas, 2008-04-29)Human T-cell leukemia/lymphoma virus (HTLV-I) is the etiological agent of the lymphoproliferative disorder, adult T-cell leukemia/lymphoma (ATLL) and the neurodegenerative disease, tropical spastic paraparesis/HTLV-I-associated ... -
beta-tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast
(American Society for Cell Biology, 2002-08)Microtubule dynamics are influenced by interactions of microtubules with cellular factors and by changes in the primary sequence of the tubulin molecule. Mutations of yeast beta-tubulin C354, which is located near the ... -
Drosophila nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitro
(American Society for Cell Biology, 2005-11)Nod, a nonmotile kinesinlike protein, plays a critical role in segregating achiasmate chromosomes during female meiosis. In addition to localizing to oocyte chromosomes, we show that functional full-length Nod-GFP (Nod(FL)-GFP) ... -
Temperature and pH govern the self-assembly of microtubules from unfertilized sea-urchin egg extracts
(COMPANY OF BIOLOGISTS LTD, 1987-02) -
EMAP, an echinoderm microtubule-associated protein found in microtubule-ribosome complexes
(COMPANY OF BIOLOGISTS LTD, 1993-02)The major non-tubulin polypeptide found associated with microtubules purified from unfertilized sea urchin eggs by cycles of pH-dependent assembly has a M(r) of 77,000. The 77,000 M(r) polypeptide is heat- and acid-labile, ... -
ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans
(American Society for Cell Biology, 2006-08)RNA interference (RNAi) is a conserved gene-silencing phenomenon that can be triggered by delivery of double-stranded RNA (dsRNA) to cells and is a widely exploited technology in analyses of gene function. Although a number ... -
Cell cycle-dependent phosphorylation of the 77 kDa echinoderm microtubule-associated protein (EMAP) in vivo and association with the p34(cdc2) kinase
(COMPANY OF BIOLOGISTS LTD, 1996-12)The most abundant microtubule-associated protein in sea urchin eggs and embryos is the 77 kDa echinoderm microtubule-associated protein (EMAP), EMAP localizes to the mitotic spindle as well as the interphase microtubule ... -
Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism
(BMJ Publishing Group, 2006-05) -
Inducible systemic RNA silencing in Caenorhabditis elegans
(American Society for Cell Biology, 2003-07)Introduction of double-stranded RNA (dsRNA) can elicit a gene-specific RNA interference response in a variety of organisms and cell types. In many cases, this response has a systemic character in that silencing of gene ... -
A small predicted stem-loop structure mediates oocyte localization of Drosophila K10 messenger-RNA
(COMPANY OF BIOLOGISTS LTD, 1995-11)The establishment of dorsoventral polarity in the Drosophila oocyte and future embryo is dependent on the efficient transport of K10 mRNA from nurse cells into the oocyte. To investigate the cis-requirements of K10 mRNA ... -
Rab11 polarization of the Drosophila oocyte: a novel link between membrane trafficking, microtubule organization, and oskar mRNA localization and translation
(COMPANY OF BIOLOGISTS LTD, 2002-01)The Drosophila embryonic body plan is specified by asymmetries that arise in the oocyte during oogenesis. These asymmetries are apparent in the subcellular distribution of key mRNAs and proteins and in the organization of ... -
Gratuitous messenger-RNA localization in drosophila oocyte
(COMPANY OF BIOLOGISTS LTD, 1995-09)Many of the genes that control pattern formation in Drosophila encode mRNAs that are localized to discrete regions of the oocyte during oogenesis, While such localization is generally assumed to be important for the ... -
Proximal femoral resection for subluxation or dislocation of the hip in spastic quadriplegia
(CAMBRIDGE UNIV PRESS, 2003-07)Management of a painful or contracted hip dislocation in individuals with severe spastic quadriplegia is difficult. Clinical and radiographic results of 12 proximal femoral resection-interposition operations performed in ... -
Vasculogenesis in the early quail blastodisc as studied with monoclonal-antibody recognizing endothelial-cells
(COMPANY OF BIOLOGISTS LTD, 1987-06) -
Sea urchin vault structure, composition, and differential localization during development
(BIOMED CENTRAL LTD, 2005-02)Background: Vaults are intriguing ribonucleoprotein assemblies with an unknown function that are conserved among higher eukaryotes. The Pacific coast sea urchin, Strongylocentrotus purpuratus, is an invertebrate model ... -
Discover protein sequence signatures from protein-protein interaction data
(BIOMED CENTRAL LTD, 2005-11-23)Background: The development of high-throughput technologies such as yeast two- hybrid systems and mass spectrometry technologies has made it possible to generate large protein-protein interaction ( PPI) datasets. Mining ...