ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Molecular Biosciences: Recent submissions
Now showing items 661-680 of 887
-
Computational Studies of Protein Structure, Dynamics, and Function in Native-like Environments
(University of Kansas, 2013-05-31)Proteins are among the four unique organic constituents of cells. They are responsible for a variety of important cell functions ranging from providing structural support to catalyzing biological reactions. They vary in ... -
Structural Studies of Chaperones and Chaperone-Tip interactions from the type III secretion systems of Yersinia and Pseudomonas
(University of Kansas, 2013-05-31)Many Gram-negative bacteria assemble a complex nanomachine, the type III secretion system (T3SS) to inject virulence proteins directly into eukaryotic cells to initiate infection. The T3SS is composed of structural and ... -
Computational Studies of Glycan Conformations in Glycoproteins
(University of Kansas, 2013-05-31)N-glycans refer to oligosaccharide chains covalently attached to the side chain of asparagine (Asn) residues, and the majority of proteins synthesized in the endoplasmic reticulum (ER) are N-glycosylated. N-glycans can ... -
STRUCTURAL AND FUNCTIONAL ANALYSIS ON HUMAN INO80 CHROMATIN REMODELING COMPLEXES
(University of Kansas, 2013-12-31)The Conaway lab previously identified and purified a human ATP-dependent chromatin remodeling complex with similarity to the Saccharomyces cerevisiae INO80 complex (65) and demonstrated that it is composed of (i) a Snf2 ... -
CHARACTERIZATION OF THE COHESIN ACETYLTRANSFERASE ECO1 AND ITS ROLE IN NUCLEAR FUNCTIONS
(University of Kansas, 2013-12-31)Sister-chromatid cohesion plays a vital role in precise chromosome segregation and genome stability. This process is carried out by the cohesin complex and its associated proteins. In addition, a growing body of evidence ... -
Mechanisms of cellular symmetry breaking in S. cerevisiae
(University of Kansas, 2013-12-31)Cell polarization is vital to diverse biological processes, from maintenance of stem cell identity to chemotaxis of neutrophils. The small GTPase Cdc42 has long been known to be a primary regulator of polarity, but the ... -
The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells
(Springer, 2014-04-30)Background Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the ... -
Genetic Dissection of the Drosophila melanogaster Female Head Transcriptome Reveals Widespread Allelic Heterogeneity
(Public Library of Science, 2014-05-08)Modern genetic mapping is plagued by the “missing heritability” problem, which refers to the discordance between the estimated heritabilities of quantitative traits and the variance accounted for by mapped causative variants. ... -
1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain
(Structural Biology Communications, 2014-04-01)The 26S proteasome is a 2.5 MDa protease dedicated to the degradation of ubiquitinated proteins in eukaryotes. The assembly of this complex containing 66 polypeptides is assisted by at least nine proteasome-specific ... -
A detailed analysis of next generation sequencing reads of microRNA expression in Barrett’s Esophagus: absolute versus relative quantification
(BioMed Central, 2014-04-04)Background Next generation sequencing (NGS) is a state of the art technology for microRNA (miRNA) analysis. The quantitative interpretation of the primary output of NGS i.e. the read counts for a miRNA sequence that can ... -
Atypical Response Regulator ChxR from Chlamydia trachomatis Is Structurally Poised for DNA Binding
(Public Library of Science, 2014-03-19)ChxR is an atypical two-component signal transduction response regulator (RR) of the OmpR/PhoB subfamily encoded by the obligate intracellular bacterial pathogen Chlamydia trachomatis. Despite structural homology within ... -
Overexpression of Nrf2 Protects against Microcystin-Induced Hepatotoxicity in Mice
(Public Library of Science, 2014-02-25)Oxidative stress and glutathione (GSH) depletion are implicated in mycocystin hepatotoxicity. To investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in microcystin-induced liver injury, Nrf2-null, ... -
Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis
(BioMed Central, 2012-06-07)Corticosteroids are standard treatment for patients with multiple sclerosis experiencing acute relapse. Because dyspeptic pain is a common side effect of this intervention, patients can be given a histamine receptor-2 ... -
Novel association of APC with intermediate filaments identified using a new versatile APC antibody
(BioMed Central, 2009-10-21)Background: As a key player in suppression of colon tumorigenesis, Adenomatous Polyposis Coli (APC) has been widely studied to determine its cellular functions. However, inconsistencies of commercially available APC ... -
LOMETS: A local meta-threading-server for protein structure prediction
(Oxford University Press, 2007-05-03)We developed LOMETS, a local threading meta-server, for quick and automated predictions of protein tertiary structures and spatial constraints. Nine state-of-the-art threading programs are installed and run in a local ... -
PBEQ-Solver for online visualization of electrostatic potential of biomolecules
(Oxford University Press, 2008-05-07)PBEQ-Solver provides a web-based graphical user interface to read biomolecular structures, solve the Poisson-Boltzmann (PB) equations and interactively visualize the electrostatic potential. PBEQ-Solver calculates (i) ... -
The Genetic Architecture of Methotrexate Toxicity Is Similar in Drosophila melanogaster and Humans
(Genetics Society of America, 2013-08-01)The severity of the toxic side effects of chemotherapy varies among patients, and much of this variation is likely genetically based. Here, we use the model system Drosophila melanogaster to genetically dissect the toxicity ... -
Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster
(Genetics Society of America, 2011-10-01)The observation that male genitalia diverge more rapidly than other morphological traits during evolution is taxonomically widespread and likely due to some form of sexual selection. One way to elucidate the evolutionary ... -
MM-align: a quick algorithm for aligning multiple-chain protein complex structures using iterative dynamic programming
(MM-align: a quick algorithm for aligning multiple-chain protein complex structures using iterative dynamic programming, 2009-05-14)Structural comparison of multiple-chain protein complexes is essential in many studies of protein–protein interactions. We develop a new algorithm, MM-align, for sequence-independent alignment of protein complex structures. ... -
GWIDD: Genome-wide protein docking database
(Oxford University Press, 2009-11-09)Structural information on interacting proteins is important for understanding life processes at the molecular level. Genome-wide docking database is an integrated resource for structural studies of protein–protein interactions ...