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Molecular Biosciences: Recent submissions
Now showing items 681-700 of 887
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γ-Tubulin regulates the anaphase-promoting complex/cyclosome during interphase
(The Rockerfeller University Press, 2010-08-02)A cold-sensitive γ-tubulin allele of Aspergillus nidulans, mipAD159, causes defects in mitotic and cell cycle regulation at restrictive temperatures that are apparently independent of microtubule nucleation defects. ... -
PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity
(The Rockerfeller University Press, 2010-11-15)DNA topoisomerase IIα (TopoIIα) is an essential chromosome-associated enzyme with activity implicated in the resolution of tangled DNA at centromeres before anaphase onset. However, the regulatory mechanism of TopoIIα ... -
The genetic control of avascular area in mouse oxygen-induced retinopathy
(Molecular Vision, 2012-02-08)Purpose: The C57BL/6ByJ and BALB/cByJ inbred strains of mice are, respectively, susceptible and resistant to oxygen-induced retinopathy (OIR). The purpose of this work was to investigate the genetic control of the retinal ... -
Development of one-step SYBR Green real-time RT-PCR for quantifying bovine viral diarrhea virus type-1 and its comparison with conventional RT-PCR
(BioMed Central, 2011-07-29)Background Bovine viral diarrhea virus (BVDV) is a worldwide pathogen in cattle and acts as a surrogate model for hepatitis C virus (HCV). One-step real-time fluorogenic quantitative reverse transcription polymerase chain ... -
Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource
(Cold Spring Harbor Laboratory Press, 2012-08-22)Genetic dissection of complex, polygenic trait variation is a key goal of medical and evolutionary genetics. Attempts to identify genetic variants underlying complex traits have been plagued by low mapping resolution in ... -
γ-Tubulin plays a key role in inactivating APC/CCdh1 at the G1–S boundary
(The Rockerfeller University Press, 2012-08-27) -
Glycan fragment database: a database of PDB-based glycan 3D structures
(Oxford University Press, 2012-10-25)The glycan fragment database (GFDB), freely available at http://www.glycanstructure.org, is a database of the glycosidic torsion angles derived from the glycan structures in the Protein Data Bank (PDB). Analogous to protein ... -
Abundance and Distribution of Transposable Elements in Two Drosophila QTL Mapping Resources
(Oxford University Press, 2013-07-19)Here we present computational machinery to efficiently and accurately identify transposable element (TE) insertions in 146 next-generation sequenced inbred strains of Drosophila melanogaster. The panel of lines we use in ... -
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells
(Nature Publishing Group, 2013-02-07)Apogossypolone (ApoG2), a novel derivative of gossypol, exhibits superior antitumor activity in Bcl-2 transgenic mice, and induces autophagy in several cancer cells. However, the detailed mechanisms are not well known. In ... -
Identification and Developmental Expression of Xenopus laevis SUMO Proteases
(Public Library of Science, 2009-12-24)SUMO proteins are small ubiquitin-related modifiers. All SUMOs are synthesized as propeptides that are post-translationally cleaved prior to conjugation. After processing, SUMOs become covalently conjugated to cellular ... -
Topoisomerase IIα Binding Domains of Adenomatous Polyposis Coli Influence Cell Cycle Progression and Aneuploidy
(Public Library of Science, 2010-04-02)Background Truncating mutations in the tumor suppressor gene APC (Adenomatous Polyposis Coli) are thought to initiate the majority of colorectal cancers. The 15- and 20-amino acid repeat regions of APC bind β-catenin and ... -
Physicochemical Characterization of a Thermostable Alcohol Dehydrogenase from Pyrobaculum aerophilum
(Public Library of Science, 2013-06-05)In this work we characterize an alcohol dehydrogenase (ADH) from the hyperthermophilic archaeon Pyrobaculum aerophilum (PyAeADHII). We have previously found that PyAeADHII has no activity when standard ADH substrates are ... -
The Functions of Myosin II and Myosin V Homologs in Tip Growth and Septation in Aspergillus nidulans
(Public Library of Science, 2012-02-16)Because of the industrial and medical importance of members of the fungal genus Aspergillus, there is considerable interest in the functions of cytoskeletal components in growth and secretion in these organisms. We have ... -
hTERT Extends the Life of Human Fibroblasts without Compromising Type I Interferon Signaling
(Public Library of Science, 2013-03-05)Primary cells are often used to study viral replication and host-virus interactions as their antiviral pathways have not been altered or inactivated; however, their use is restricted by their short lifespan. Conventional ... -
Protein Docking by the Interface Structure Similarity: How Much Structure Is Needed?
(Public Library of Science, 2012-02-13)The increasing availability of co-crystallized protein-protein complexes provides an opportunity to use template-based modeling for protein-protein docking. Structure alignment techniques are useful in detection of remote ... -
The Finer Points of Filopodia
(Public Library of Science, 2009-06-30) -
PPARβ Regulates Liver Regeneration by Modulating Akt and E2f Signaling
(Public Library of Science, 2013-06-18)The current study tests the hypothesis that peroxisome proliferator-activated receptor β (PPARβ) has a role in liver regeneration due to its effect in regulating energy homeostasis and cell proliferation. The role of PPARβ ... -
HAAD: A Quick Algorithm for Accurate Prediction of Hydrogen Atoms in Protein Structures
(Public Library of Science, 2009-08-20)Hydrogen constitutes nearly half of all atoms in proteins and their positions are essential for analyzing hydrogen-bonding interactions and refining atomic-level structures. However, most protein structures determined by ... -
PROTS-RF: A Robust Model for Predicting Mutation-Induced Protein Stability Changes
(Public Library of Science, 2012-10-15)The ability to improve protein thermostability via protein engineering is of great scientific interest and also has significant practical value. In this report we present PROTS-RF, a robust model based on the Random Forest ... -
Evidence for a Transport-Trap Mode of Drosophila melanogaster gurken mRNA Localization
(Public Library of Science, 2010-11-12)The Drosophila melanogaster gurken gene encodes a TGF alpha-like signaling molecule that is secreted from the oocyte during two distinct stages of oogenesis to define the coordinate axes of the follicle cell epithelium ...