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Molecular Biosciences: Recent submissions
Now showing items 261-280 of 887
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The Regulation of Musashi RNA Binding Proteins and the Implications for Cancer Therapy
(University of Kansas, 2015-12-31)RNA-binding protein and stem cell regulator, Musashi-1 (MSI1) is overexpressed in a broad range of human cancers and associated with poor clinical outcome. MSI1 encourages tumorigenesis by promoting Notch and Wnt signaling, ... -
Unassisted Transport of N-acetyl-L-tryptophanamide through Membrane: Experiment and Simulation of Kinetics
(American Chemical Society, 2012-03-08)Cellular transport machinery, such as channels and pumps, is working against the background of unassisted material transport through membranes. The permeation of a blocked tryptophan through a 1,2-Dioleoyl-sn-glycero-3-p ... -
Mechanistic and structural studies of the N-hydroxylating flavoprotein monooxygenases
(Elsevier, 2011-12)The N-hydroxylating flavoprotein monooxygenases are siderophore biosynthetic enzymes that catalyze the hydroxylation of the sidechain amino-group of ornithine or lysine or the primary amino-group of putrescine. This ... -
Experiments and comprehensive simulations of the formation of a helical turn
(American Chemical Society, 2012-06-14)We consider the kinetics and thermodynamics of a helical turn formation in the peptide Ac-WAAAH-NH2. NMR measurements indicate that the peptide has significant tendency to form a structure of a helical turn, while temperature ... -
The Kinetics of helix unfolding: Molecular dynamics simulations with Milestoning
(American Chemical Society, 2009-01-02)The unfolding process of a helical heteropeptide is studied by computer simulation in explicit solvent. A combination of a functional optimization to determine the reaction coordinate and short time trajectories between ... -
Structure-Based Design of Non-Natural Amino Acid Inhibitors of Amyloid Fibrillation
(Nature Publishing Group, 2011-07-07)Many globular and natively disordered proteins can convert into amyloid fibers. These fibers are associated with numerous pathologies1 as well as with normal cellular functions2,3, and frequently form during protein ... -
Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro
(ACS, 2015-04-15)The aggregation of the microtubule-associated protein tau is a seminal event in many neurodegenerative diseases, including Alzheimer’s disease. The inhibition or reversal of tau aggregation is therefore a potential therapeutic ... -
Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction
(ACS, 2015-03-17)HuR, an RNA binding protein, binds to adenine- and uridine-rich elements (ARE) in the 3′-untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is highly abundant in many types of cancer, ... -
Studies on Endamoeba histolytica, its accompanying bacteria, and Blastocystis hominis
(University of Kansas, 1932) -
Two Structures of a Thiazolinyl Imine Reductase from Yersinia enterocolitica Provide Insight into Catalysis and Binding to the Nonribosomal Peptide Synthetase Module of HMWP1
(ACS, 2012-11-06)The thiazolinyl imine reductase from Yersinia enterocolitica (Irp3) catalyzes the NADPH-dependent reduction of a thiazoline ring in an intermediate for the formation of the siderophore yersiniabactin. Two structures of ... -
The Hemophore HasA from Yersinia pestis (HasAyp) Coordinates Hemin with a Single Residue, Tyr75, and with Minimal Conformational Change
(ACS, 2013-04-23)Hemophores from Serratia marcescens (HasAsm) and Pseudomonas aeruginosa (HasAp) bind hemin between two loops, which harbor the axial ligands H32 and Y75. Hemin binding to the Y75 loop triggers closing of the H32 loop and ... -
Structure and Biophysics of Type III Secretion in Bacteria
(ACS, 2013-04-16)Many plant and animal bacterial pathogens assemble a needle-like nanomachine, the type III secretion system (T3SS), to inject virulence proteins directly into eukaryotic cells to initiate infection. The ability of bacteria ... -
Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors
(ACS, 2016-02-09)The natural product α-hydroxytropolones manicol and β-thujaplicinol inhibit replication of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2, respectively) at nontoxic concentrations. Because these were originally developed ... -
Dissecting Complex Traits Using the Drosophila Synthetic Population Resource
(Elsevier, 2014-08-28)For most complex traits we have a poor understanding of the positions, phenotypic effects, and population frequencies of the underlying genetic variants contributing to their variation. Recently, several groups have developed ... -
Secondary nucleating sequences affect kinetics and thermodynamics of tau aggregation
(ACS, 2011-12-20)Tau protein was scanned for highly amyloidogenic sequences in amphiphilic motifs (X)nZ, Z(X)nZ (n≥2) or (XZ)n (n≥2), where X is a hydrophobic residue and Z is a charged or polar residue. N-acetyl peptides homologous to ... -
Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms
(ACS, 2011-11-08)The microtubule-associated protein tau exists as six isoforms created through the splicing of the second, third, and tenth exons. The isoforms are classified by their number of N-terminal exons (0N, 1N or 2N) and by their ... -
Pseudo-hyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization
(ACS, 2009-06-30)The microtubule-associated protein tau, in a hyperphosphorylated form, aggregates into insoluble paired-helical filaments (PHFs) in Alzheimer’s disease (AD) and other tauopathies. In AD, there are approximately 8 mol of ... -
Protein Dynamics and Ion Traffic in Bacterioferritin
(ACS, 2012-12-11)Bacterioferritin (Bfr) is a spherical protein composed of 24 subunits and 12 heme molecules. Bfrs contribute to regulate iron homeostasis in bacteria by capturing soluble but potentially toxic Fe2+ and by compartmentalizing ... -
pH Dependence of Catalysis by Pseudomonas aeruginosa Isochorismate-Pyruvate Lyase: Implications for Transition State Stabilization and the Role of Lysine 42
(ACS, 2011-08-23)An isochorismate-pyruvate lyase with adventitious chorismate mutase activity from Pseudomonas aerugionsa (PchB) achieves catalysis of both pericyclic reactions in part by the stabilization of reactive conformations and in ... -
Pericyclic reactions catalyzed by chorismate-utilizing enzymes
(ACS, 2011-09-06)One of the fundamental questions of enzymology is how catalytic power is derived. This review focuses on recent developments in the structure-function relationships of chorismate-utilizing enzymes involved in siderophore ...