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    Structure and Biophysics of Type III Secretion in Bacteria

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    Chatterjee_ACS_2013.pdf (2.260Mb)
    Issue Date
    2013-04-16
    Author
    Chatterjee, Srirupa
    Chaudhury, Sukanya
    McShan, Andrew C.
    Kaur, Kawaljit
    De Guzman, Roberto N.
    Publisher
    ACS
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    Copyright © 2013 American Chemical Society
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    Abstract
    Many plant and animal bacterial pathogens assemble a needle-like nanomachine, the type III secretion system (T3SS), to inject virulence proteins directly into eukaryotic cells to initiate infection. The ability of bacteria to inject effectors into host cells is essential for infection, survival, and pathogenesis for many Gram-negative bacteria, including Salmonella, Escherichia, Shigella, Yersinia, Pseudomonas, and Chlamydia spp. These pathogens are responsible for a wide variety of diseases, such as typhoid fever, large-scale food-borne illnesses, dysentery, bubonic plague, secondary hospital infections, and sexually transmitted diseases. The T3SS consists of structural and nonstructural proteins. The structural proteins assemble the needle apparatus, which consists of a membrane-embedded basal structure, an external needle that protrudes from the bacterial surface, and a tip complex that caps the needle. Upon host cell contact, a translocon is assembled between the needle tip complex and the host cell, serving as a gateway for translocation of effector proteins by creating a pore in the host cell membrane. Following delivery into the host cytoplasm, effectors initiate and maintain infection by manipulating host cell biology, such as cell signaling, secretory trafficking, cytoskeletal dynamics, and the inflammatory response. Finally, chaperones serve as regulators of secretion by sequestering effectors and some structural proteins within the bacterial cytoplasm. This review will focus on the latest developments and future challenges concerning the structure and biophysics of the needle apparatus.
    URI
    http://hdl.handle.net/1808/23751
    DOI
    https://doi.org/10.1021/bi400160a
    Collections
    • Molecular Biosciences Scholarly Works [530]
    Citation
    Chatterjee, S., Chaudhury, S., McShan, A. C., Kaur, K., & De Guzman, R. N. (2013). Structure and Biophysics of Type III Secretion in Bacteria. Biochemistry, 52(15), 2508–2517. http://doi.org/10.1021/bi400160a

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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