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    Dissecting Complex Traits Using the Drosophila Synthetic Population Resource

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    Issue Date
    2014-08-28
    Author
    Long, Anthony D.
    Macdonald, Stuart J.
    King, Elizabeth G.
    Publisher
    Elsevier
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    Copyright Elsevier
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    Abstract
    For most complex traits we have a poor understanding of the positions, phenotypic effects, and population frequencies of the underlying genetic variants contributing to their variation. Recently, several groups have developed multi-parent advanced intercross mapping panels in different model organisms in an attempt to improve our ability to characterize causative genetic variants. These panels are powerful and are particularly well suited to the dissection of phenotypic variation generated by rare alleles and loci segregating multiple functional alleles. We describe studies using one such panel, the Drosophila Synthetic Population Resource, and the implications for our understanding of the genetic basis of complex traits. In particular, we note that many loci of large effect appear to be multiallelic. If multiallelism is a general rule, analytical approaches designed to identify multiallelic variants should be a priority for both genome wide association studies and multi-parental panels.
    URI
    http://hdl.handle.net/1808/23717
    DOI
    https://doi.org/10.1016/j.tig.2014.07.009
    Collections
    • Molecular Biosciences Scholarly Works [537]
    Citation
    Long, Anthony D., Stuart J. Macdonald, and Elizabeth G. King. “Dissecting Complex Traits Using the Drosophila Synthetic Population Resource.” Trends in genetics : TIG 30.11 (2014): 488–495.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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