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Molecular Biosciences: Recent submissions
Now showing items 181-200 of 887
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Draft Genome Sequence of Lysinibacillus fusiformis Strain Juneja, a Laboratory-Derived Pathogen of Drosophila melanogaster
(American Society for Microbiology, 2018-02-01)Drosophila melanogaster is a model for the study of innate immunity, yet we have limited knowledge of its natural pathogens. In this study, we sequenced the genome of Lysinibacillus fusiformis strain Juneja, isolated from ... -
MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma
(Impact Journals, 2018-04-20)Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and the prognosis of HCC patients, especially those with metastasis, remains extremely poor. This is partly due to unclear molecular mechanisms ... -
Bacterial Quorum Sensing and Microbial Community Interactions
(American Society for Microbiology, 2018-05-22)Many bacteria use a cell-cell communication system called quorum sensing to coordinate population density-dependent changes in behavior. Quorum sensing involves production of and response to diffusible or secreted signals, ... -
Transmission Dynamics of Bovine Anaplasmosis in a Cattle Herd
(Hindawi Publishing Corporation, 2018-05-02)Bovine anaplasmosis is an infectious disease of cattle caused by the obligate intercellular bacterium, Anaplasma marginale, and it primarily occurs in tropical and subtropical regions of the world. In this study, an ... -
DISCOVERY OF GENETIC CORRELATES IMPORTANT FOR CHLAMYDIA INFECTION AND PATHOGENESIS
(University of Kansas, 2017-08-31)Chlamydia species are responsible for over 1.2 million reports of bacterial sexually transmitted infections in the United States; a number that has been steadily increasing for the past decade. Worldwide, a cumulative 131 ... -
Ligand Binding Pathways and Conformational Transitions of the HIV Protease
(Biochemistry, 2018-03-06)It is important to determine the binding pathways and mechanisms of ligand molecules to target proteins to effectively design therapeutic drugs. Molecular dynamics (MD) is a promising computational tool that allows us to ... -
Application of RAD-seq in Evolutionary Genomics of Non-Model Organisms
(University of Kansas, 2017-05-31)Next generation sequencing (NGS) technologies are revolutionizing how we study genetics and evolution in the modern world. Data is generated at such a fast pace that scientists are struggling to keep up with the innovations ... -
Studies on the nutrition of Clostridium welchii in relation to toxin production
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Studies on natural immunity in the cat
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A Framework for Studying Crucial Steps in Proteasome Core Particle Assembly
(University of Kansas, 2017-08-31)The ability of proteins to repeatedly and reliably self-assemble in the cell is a critical element of the maintenance of life. Despite this, the mechanisms that underlie these events are poorly understood. The proteasome ... -
Biophysical studies of the Burkholderia minor translocon protein BipC by NMR and CD spectroscopy
(University of Kansas, 2017-05-31)Abstract The type III secretion system (T3SS) provides many Gram-negative pathogens a tool to initiate, maintain and proliferate infection in the host. The T3SS is a syringe-like apparatus composed of a base that transverses ... -
O-GlcNAc Regulates Erythroid Gene Transcription
(University of Kansas, 2017-08-31)O-GlcNAc is a post-translational modification on serine or threonine residues by β-N-acetylglucosamine. O-GlcNAc is added and removed from serine and threonine residues by the O-GlcNAc processing enzymes, O-GlcNAc-transferase ... -
Characterization of Small Molecule Scaffolds that Bind to the Shigella Type III Secretion System Protein IpaD
(Wiley, 2017-09-21)Many pathogens such as Shigella and other bacteria assemble the type III secretion system (T3SS) nanoinjector to inject virulence proteins into their target cells to cause infectious diseases in humans. The rise of drug ... -
Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression
(University of Kansas, 2017-05-31)It has been reported that long non-coding RNA lincRNA-p21 is induced upon radiation and chemotherapy. This induction contributes to DNA-damage repair, cell death and cell cycle regulation. In this study, we focused on ... -
Identifying cellular kinases that regulate HSV-1 ICP0 activities and viral replication.
(University of Kansas, 2016-12-31)Herpes simplex virus 1 (HSV-1) infects a significant number of people worldwide and is the number one cause of infectious blindness in western industrialized countries. HSV-1 causes a lifelong latent infection that can be ... -
Template-Based Modeling of Protein-RNA Interactions
(Public Library of Science, 201-09-23)Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding ... -
EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans
(Public Library of Science, 2016-02-10)Directed neuroblast and neuronal migration is important in the proper development of nervous systems. In C. elegans the bilateral Q neuroblasts QR (on the right) and QL (on the left) undergo an identical pattern of cell ... -
Cellular Growth Arrest and Persistence from Enzyme Saturation
(Public Library of Science, 2016-03-24)Metabolic efficiency depends on the balance between supply and demand of metabolites, which is sensitive to environmental and physiological fluctuations, or noise, causing shortages or surpluses in the metabolic pipeline. ... -
Annual Greenland accumulation rates (2009–2012) from airborne snow radar
(European Geosciences Union, 2016-08-11)Contemporary climate warming over the Arctic is accelerating mass loss from the Greenland Ice Sheet through increasing surface melt, emphasizing the need to closely monitor its surface mass balance in order to improve ...