The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
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Issue Date
2020-03-31Author
Alhammad, Yousef M. O.
Fehr, Anthony R.
Publisher
MDPI
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© 2020 by the authors.
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Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection. ADP-ribose is covalently attached to target proteins by poly-ADP-ribose polymerases (PARPs), using nicotinamide adenine dinucleotide (NAD+) as a substrate. This modification can have a wide variety of effects on proteins including alteration of enzyme activity, protein–protein interactions, and protein stability. Several PARPs are induced by interferon (IFN) and are known to have antiviral properties, implicating ADP-ribosylation in the host defense response and suggesting that viral macrodomains may counter this response. Recent studies have demonstrated that viral macrodomains do counter the innate immune response by interfering with PARP-mediated antiviral defenses, stress granule formation, and pro-inflammatory cytokine production. Here, we will describe the known functions of the viral macrodomains and review recent literature demonstrating their roles in countering PARP-mediated antiviral responses.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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Citation
Alhammad, Y., & Fehr, A. R. (2020). The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation. Viruses, 12(4), 384. https://doi.org/10.3390/v12040384
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