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dc.contributor.authorBravo Núñez, María Angélica
dc.contributor.authorSabbarini, Ibrahim M.
dc.contributor.authorEide, Lauren E.
dc.contributor.authorUnckless, Robert L.
dc.contributor.authorZanders, Sarah E.
dc.date.accessioned2020-11-10T22:30:50Z
dc.date.available2020-11-10T22:30:50Z
dc.date.issued2020-08-13
dc.identifier.citationBravo Núñez, M. A., Sabbarini, I. M., Eide, L. E., Unckless, R. L., & Zanders, S. E. (2020). Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers. eLife, 9, e57936. https://doi.org/10.7554/eLife.57936en_US
dc.identifier.urihttp://hdl.handle.net/1808/30826
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractKiller meiotic drivers are genetic parasites that destroy ‘sibling’ gametes lacking the driver allele. The fitness costs of drive can lead to selection of unlinked suppressors. This suppression could involve evolutionary tradeoffs that compromise gametogenesis and contribute to infertility. Schizosaccharomyces pombe, an organism containing numerous gamete (spore)-killing wtf drivers, offers a tractable system to test this hypothesis. Here, we demonstrate that in scenarios analogous to outcrossing, wtf drivers generate a fitness landscape in which atypical spores, such as aneuploids and diploids, are advantageous. In this context, wtf drivers can decrease the fitness costs of mutations that disrupt meiotic fidelity and, in some circumstances, can even make such mutations beneficial. Moreover, we find that S. pombe isolates vary greatly in their ability to make haploid spores, with some isolates generating up to 46% aneuploid or diploid spores. This work empirically demonstrates the potential for meiotic drivers to shape the evolution of gametogenesis.en_US
dc.description.sponsorshipStowers Institute for Medical Researchen_US
dc.description.sponsorshipMarch of Dimes Foundation Basil O'Connor Starter Scholar Research Award No. 5-FY18-58en_US
dc.description.sponsorshipKinship Foundation Searle Scholars Awarden_US
dc.description.sponsorshipNational Institute of General Medical Sciences R00GM114436en_US
dc.description.sponsorshipNational Institute of General Medical Sciences DP2GM132936en_US
dc.description.sponsorshipNational Cancer Institute F99CA234523en_US
dc.description.sponsorshipUniversity of Kansasen_US
dc.publishereLife Sciences Publicationsen_US
dc.rights© 2020, Bravo Núñez et al.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleAtypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic driversen_US
dc.typeArticleen_US
kusw.kuauthorUnckless, Robert L.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.7554/eLife.57936en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-6554-8814en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-6490-7056en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8586-7137en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1867-986Xen_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC7426094en_US
dc.rights.accessrightsopenAccessen_US


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© 2020, Bravo Núñez et al.
Except where otherwise noted, this item's license is described as: © 2020, Bravo Núñez et al.