Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers
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Issue Date
2020-08-13Author
Bravo Núñez, María Angélica
Sabbarini, Ibrahim M.
Eide, Lauren E.
Unckless, Robert L.
Zanders, Sarah E.
Publisher
eLife Sciences Publications
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© 2020, Bravo Núñez et al.
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Killer meiotic drivers are genetic parasites that destroy ‘sibling’ gametes lacking the driver allele. The fitness costs of drive can lead to selection of unlinked suppressors. This suppression could involve evolutionary tradeoffs that compromise gametogenesis and contribute to infertility. Schizosaccharomyces pombe, an organism containing numerous gamete (spore)-killing wtf drivers, offers a tractable system to test this hypothesis. Here, we demonstrate that in scenarios analogous to outcrossing, wtf drivers generate a fitness landscape in which atypical spores, such as aneuploids and diploids, are advantageous. In this context, wtf drivers can decrease the fitness costs of mutations that disrupt meiotic fidelity and, in some circumstances, can even make such mutations beneficial. Moreover, we find that S. pombe isolates vary greatly in their ability to make haploid spores, with some isolates generating up to 46% aneuploid or diploid spores. This work empirically demonstrates the potential for meiotic drivers to shape the evolution of gametogenesis.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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Citation
Bravo Núñez, M. A., Sabbarini, I. M., Eide, L. E., Unckless, R. L., & Zanders, S. E. (2020). Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers. eLife, 9, e57936. https://doi.org/10.7554/eLife.57936
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