Show simple item record

dc.contributor.authorUnckless, Robert L.
dc.contributor.authorOrr, H. Allen
dc.date.accessioned2020-10-19T15:26:10Z
dc.date.available2020-10-19T15:26:10Z
dc.date.issued2020-01-15
dc.identifier.citationUnckless, R. L., & Orr, H. A. (2020). The Population Genetics of Evolutionary Rescue in Diploids: X Chromosomal versus Autosomal Rescue. The American naturalist, 195(3), 561–568. https://doi.org/10.1086/707139en_US
dc.identifier.urihttp://hdl.handle.net/1808/30781
dc.description.abstractMost population genetic theory assumes that populations adapt to an environmental change without a change in population size. However, environmental changes might be so severe that populations decline in size and, without adaptation, become extinct. This “evolutionary rescue” scenario differs from traditional models of adaptation in that rescue involves a race between adaptation and extinction. While most previous work has usually focused on models of evolutionary rescue in haploids, here we consider diploids. In many species, diploidy introduces a novel feature into adaptation: adaptive evolution might occur either on sex chromosomes or on autosomes. Previous studies of nonrescue adaptation revealed that the relative rates of adaptation on the X chromosome versus autosomes depend on the dominance of beneficial mutations, reflecting differences in effective population size and the efficacy of selection. Here, we extend these results to evolutionary rescue and find that, given equal-sized chromosomes, there is greater parameter space in which the X is more likely to contribute to adaptation than the autosomes relative to standard nonrescue models. We also discuss how subtle effects of dominance can increase the chance of evolutionary rescue in diploids when absolute heterozygote fitness is close to 1. These effects do not arise in standard nonrescue models.en_US
dc.description.sponsorshipR00GM114714en_US
dc.description.sponsorshipR01AI139154en_US
dc.description.sponsorshipUniversity of Rochesteren_US
dc.publisherUniversity of Chicago Pressen_US
dc.rights© 2020 by The University of Chicago. All rights reserved.en_US
dc.subjectAdaptationen_US
dc.subjectAutosomesen_US
dc.subjectEnvironmental changeen_US
dc.subjectEvolutionary rescueen_US
dc.subjectSex chromosomesen_US
dc.titleThe Population Genetics of Evolutionary Rescue in Diploids: X Chromosomal versus Autosomal Rescueen_US
dc.typeArticleen_US
kusw.kuauthorUnckless, Robert L.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1086/707139en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8586-7137en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC7252526en_US
dc.rights.accessrightsembargoedAccessen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record