Estrogen signaling impacts temporomandibular joint and periodontal disease pathology

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Issue Date
2020-04-30Author
Robinson, Jennifer L.
Johnson, Pamela M.
Kister, Karolina
Yin, Michael T.
Chen, Jing
Wadhwa, Sunil
Publisher
Springer Verlag
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Rights
© 2019, Springer Nature.
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Show full item recordAbstract
Women experience a higher incidence of oral diseases including periodontal diseases and temporomandibular joint disease (TMD) implicating the role of estrogen signaling in disease pathology. Fluctuating levels of estrogen during childbearing age potentiates facial pain, high estrogen levels during pregnancy promote gingivitis, and low levels of estrogen during menopause predisposes the TMJ to degeneration and increases alveolar bone loss. In this review, an overview of estrogen signaling pathways in vitro and in vivo that regulate pregnancy-related gingivitis, TMJ homeostasis, and alveolar bone remodeling is provided. Deciphering the specific estrogen signaling pathways for individual oral diseases is crucial for potential new drug therapies to promote and maintain healthy tissue.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
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Citation
Robinson, J. L., Johnson, P. M., Kister, K., Yin, M. T., Chen, J., & Wadhwa, S. (2020). Estrogen signaling impacts temporomandibular joint and periodontal disease pathology. Odontology, 108(2), 153–165. https://doi.org/10.1007/s10266-019-00439-1
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