Chemical and Petroleum Engineering Scholarly Works
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MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents
(Springer Verlag, 2017-12)An innovative approach for cardiac regeneration following injury is to induce endogenous cardiomyocyte (CM) cell cycle re-entry. In the present study, CMs from adult rat hearts were isolated and transfected with cel-miR-67 ... -
Deciphering the role of substrate stiffness to enhance internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers
(Royal Society of Chemistry, 2018-04-06)This study investigates the role of substrate stiffness on non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize hASCs expression of vascular endothelial growth factor (VEGF). The ... -
Microfluidic Engineering of Exosomes: Editing Cellular Messages for Precision Therapeutics
(Royal Society of Chemistry, 2018-05-04)Studying extracellular vesicle (EV), particularly exosomes, is holding great promise, yet technically challenging in defining such small and molecularly diverse nanovesicles. With intrinsic molecular payload and biodegradability, ... -
Polymeric Nanohybrids as a New Class of Therapeutic Biotransporters
(Wiley, 2016-06)A possible solution to enhance existing drug and gene therapies is to develop hybrid nanocarriers capable of delivering therapeutic agents in a controlled and targeted manner. This goal can be achieved by designing nanohybrid ... -
Electrospun Nafion®/Polyphenylsulfone Composite Membranes for Regenerative Hydrogen Bromine Fuel Cells
(MDPI, 2016-02-29)The regenerative H2/Br2-HBr fuel cell, utilizing an oxidant solution of Br2 in aqueous HBr, shows a number of benefits for grid-scale electricity storage. The membrane-electrode assembly, a key component of a fuel cell, ... -
Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment
(Impact Journals, 2016-06-07)Triple negative breast cancers are an aggressive subtype of breast cancer, characterized by the lack of estrogen receptor, progesterone receptor and Her2 expression. Triple negative breast cancers are non-responsive to ... -
Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration†
(Royal Society of Chemistry, 2016-03-31)A nanocomposite hydrogel with photocrosslinkable micro-porous networks and a nanoclay component was successfully prepared to control the release of growth factor-rich stem cell secretome. The proven pro-angiogenic and ... -
Nanocomposite hydrogels: an emerging biomimetic platform for myocardial therapy and tissue engineering
(Future Medicine, 2015-05)Recent years have seen a significant rise in patient survival rate after myocardial infarction, commonly known as heart attack. This is mainly due to improvement in hospital instrument facilities, clinical management system, ... -
Subcritical CO2 Sintering of Microspheres of Different Polymeric Materials to Fabricate Scaffolds for Tissue Engineering
(Elsevier, 2013-12-01)The aim of this study was to use CO2 at sub-critical pressures as a tool to sinter 3D, macroporous, microsphere-based scaffolds for bone and cartilage Tissue Engineering Porous scaffolds composed of ~200 µm microspheres ... -
Effect of different sintering methods on bioactivity and release of proteins from PLGA microspheres
(Elsevier, 2013-10)Macromolecule release from poly(d,l-lactide-co-glycolide) (PLGA) microspheres has been well-characterized, and is a popular approach for delivering bioactive signals from tissue-engineered scaffolds. However, the effect ... -
Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy
(Wiley, 2016-03-08)Cardiovascular disease is a leading cause of death worldwide. Since adult cardiac cells are limited in their proliferation, cardiac tissue with dead or damaged cardiac cells downstream of the occluded vessel does not ... -
Phospholipid Composition Modulates Carbon Nanodiamond-Induced Alterations in Phospholipid Domain Formation
(American Chemical Society, 2015-05-12)The focus of this work is to elucidate how phospholipid composition can modulate lipid nanoparticle interactions in phospholipid monolayer systems. We report on alterations in lipid domain formation induced by anionically ... -
Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering
(Wiley, 2011-10)Cell sources and tissue integration between cartilage and bone regions are critical to successful osteochondral regeneration. In this study, human umbilical cord mesenchymal stromal cells (hUCMSCs), derived from Wharton’s ... -
Using chondroitin sulfate to improve the viability and biosynthesis of chondrocytes encapsulated in interpenetrating network (IPN) hydrogels of agarose and poly(ethylene glycol) diacrylate
(Springer Verlag, 2012-01)We recently introduced agarose-poly(ethylene glycol) diacrylate (PEGDA) interpenetrating network (IPN) hydrogels to cartilage tissue engineering that were able to encapsulate viable cells and provide a significant improvement ... -
Three-dimensional Macroscopic Scaffolds With a Gradient in Stiffness for Functional Regeneration of Interfacial Tissues
(Wiley, 2010-09-01)A novel approach has been demonstrated to construct biocompatible, macroporous 3-D tissue engineering scaffolds containing a continuous macroscopic gradient in composition that yields a stiffness gradient along the axis ... -
PLGA-chitosan/PLGA-alginate Nanoparticle Blends as Biodegradable Colloidal Gels for Seeding Human Umbilical Cord Mesenchymal Stem Cells
(Wiley, 2011-03-01)The natural polymers chitosan and alginate represent an attractive material choice for biodegradable inplants. These were used as coating materials to make positively and negatively charged PLGA nanoparticles, respectively. ... -
The bioactivity of agarose-PEGDA interpenetrating network hydrogels with covalently immobilized RGD peptides and physically entrapped aggrecan
(Elsevier, 2014-04)Our previous reports of interpenetrating networks (IPNs) have demonstrated drastic improvements in mechanical performance relative to individual constituent networks while maintaining viability of encapsulated cells. The ... -
A multilayered microfluidic blood vessel-like structure
(Springer Verlag, 2015-10)There is an immense need for tissue engineered blood vessels. However, current tissue engineering approaches still lack the ability to build native blood vessel-like perfusable structures with multi-layered vascular walls. ... -
Adhesion of Pancreatic Beta Cells to Biopolymer Films
(Wiley, 2009-08)Dramatic reversal of Type 1 diabetes in patients receiving pancreatic islet transplants continues to prompt vigorous research concerning the basic mechanisms underlying patient turnaround. At the most fundamental level, ... -
Tuning mechanical performance of poly(ethylene glycol) and agarose interpenetrating network hydrogels for cartilage tissue engineering
(Elsevier, 2013-08-06)Hydrogels are attractive for tissue engineering applications due to their incredible versatility, but they can be limited in cartilage tissue engineering applications due to inadequate mechanical performance. In an effort ...
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