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dc.contributor.authorFranklin, Meghan Whitney
dc.contributor.authorNepomnyachiy, Sergey
dc.contributor.authorFeehan, Ryan
dc.contributor.authorBen-Tal, Nir
dc.contributor.authorKolodny, Rachel
dc.contributor.authorSlusky, Joanna S.G.
dc.descriptionPreprint now published in Structure doi: 10.1016/j.str.2018.06.007en_US
dc.description.abstractThere are around 100 types of integral outer membrane proteins in each Gram negative bacteria. All of these proteins have the same fold—an up-down β-barrel. It has been suggested that all membrane β-barrels other than lysins are homologous. Here we suggest that β-barrels of efflux pumps have converged on this fold as well. By grouping structurally-solved outer membrane β-barrels (OMBBs) by sequence we find evidence that the membrane environment may have led to convergent evolution of the barrel fold. Specifically, the lack of sequence linkage to other barrels coupled with distinctive structural differences, such as differences in strand tilt and barrel radius, suggest that efflux pumps have evolutionarily converged on the barrel. Finally, we find a possible ancestor for the OMBB efflux pumps as they are related to periplasmic components of the same pumps.en_US
dc.rightsCopyright 2018, The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.en_US
dc.titleEfflux Pumps Represent Possible Evolutionary Convergence onto the Beta Barrel Folden_US
kusw.kuauthorSlusky, Joanna
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oanotes2019/06/19: Author gave permission for preprint to be shared in KUSW: From: Slusky, Joanna <> Sent: Tuesday, January 29, 2019 9:27 AM To: Reed, Marianne A. <> Subject: Re: Your research featured in KU Today

Hi Marianne,

Sure. I'm always happy to have a bigger audience for my work. An early version of the paper is already on biorXiv

What are the steps for getting that or a more recent version of the paper into scholar works?

Thanks again, Joanna

Joanna Slusky, Ph.D. Assistant Professor, Computational Biology and Molecular Biosciences University of Kansas

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