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dc.contributor.authorSanchez, James F.
dc.contributor.authorChiang, Yi-Ming
dc.contributor.authorSzewczyk, Edyta
dc.contributor.authorDavidson, Ashley D.
dc.contributor.authorAhuja, Manmeet
dc.contributor.authorOakley, C. Elizabeth
dc.contributor.authorBok, Jin Woo
dc.contributor.authorKeller, Nancy P.
dc.contributor.authorOakley, Berl R.
dc.contributor.authorWang, Clay C. C.
dc.identifier.citationSanchez, J. F., Chiang, Y.-M., Szewczyk, E., Davidson, A. D., Ahuja, M., Oakley, C. E., … Wang, C. C. C. (2010). Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans. Molecular bioSystems, 6(3), 587–593.
dc.description.abstractF-9775A and F-9775B are cathepsin K inhibitors that arise from a chromatin remodelling deletant strain of Aspergillus nidulans. A polyketide synthase gene has been determined to be responsible for their formation and for the simpler, archetypical polyketide orsellinic acid. We have discovered simple culture conditions that result in the production of the three compounds, and this facilitates analysis of the genes responsible for their synthesis. We have now analysed the F9775/orsellinic acid gene cluster using a set of targeted deletions. We find that the polyketide synthase alone is required for orsellinic acid biosynthesis and only two additional genes in the cluster are required for F9775 A and B synthesis. Our deletions also yielded the bioactive metabolites gerfelin and diorcinol.en_US
dc.publisherRoyal Society of Chemistryen_US
dc.titleMolecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans†,‡en_US
kusw.kuauthorOakley, Berl R.
kusw.kuauthorOakley, C. Elizabeth
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oanotesPer SHERPA/RoMEO 6/22/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions:

Authors pre-print on any website, including arXiv and RePEC Author's post-print on author's personal website immediately Author's post-print on open access repository after an embargo period of between 12 months and 48 months Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months Author's post-print may be used to update arXiv and RepEC Publisher's version/PDF cannot be used Must link to publisher version with DOI Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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