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dc.contributor.authorHueston, Jennifer L.
dc.contributor.authorSuprenant, Kathy A.
dc.date.accessioned2017-06-09T17:27:02Z
dc.date.available2017-06-09T17:27:02Z
dc.date.issued2009-08
dc.identifier.citationHueston, J. L. and Suprenant, K. A. (2009), Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans. Dev. Dyn., 238: 1878–1886. doi:10.1002/dvdy.22007en_US
dc.identifier.urihttp://hdl.handle.net/1808/24463
dc.descriptionThis is the peer reviewed version of the following article: Hueston, J. L. and Suprenant, K. A. (2009), Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans. Dev. Dyn., 238: 1878–1886. doi:10.1002/dvdy.22007, which has been published in final form at http://doi.org/10.1002/dvdy.22007. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.description.abstractEMAP-like proteins (ELPs) are conserved microtubule-binding proteins that function during cell division and in the behavior of post-mitotic cells. In C. elegans, ELP-1 is broadly expressed in many cells and tissues including the touch receptor neurons and body wall muscle. Within muscle, ELP-1 is associated with a microtubule network that is closely opposed to the integrin-based adhesion sites called dense bodies. To examine ELP-1 function we utilized an elp-1 RNA interference assay and screened for synthetic interactions with mutated adhesion site proteins. We reveal a synthetic lethal relationship between ELP-1 and the dystrophin-like protein, DYS-1. Reduction of ELP-1 in a dystrophin [dys-1(cx18)] mutant results in adult animals with motility defects, splayed and hypercontracted muscle with altered cholinergic signaling. Worms fill with vesicles, become flaccid and die. We conclude that ELP-1 is a genetic modifier of a C. elegans model of muscular dystrophy.en_US
dc.publisherWileyen_US
dc.subjectMuscle physiologyen_US
dc.subjectCytoskeletonen_US
dc.subjectCell adhesionen_US
dc.subjectCholinergic agentsen_US
dc.subjectMuscular dystrophyen_US
dc.titleLoss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegansen_US
dc.typeArticleen_US
kusw.kuauthorHueston, Jennifer L.
kusw.kuauthorSuprenant, Kathy A.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1002/dvdy.22007en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2942758en_US
dc.rights.accessrightsopenAccess


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