ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated. If you have any questions, please contact Marianne Reed at mreed@ku.edu .

Show simple item record

dc.contributor.authorHueston, Jennifer L.
dc.contributor.authorSuprenant, Kathy A.
dc.date.accessioned2017-06-09T17:27:02Z
dc.date.available2017-06-09T17:27:02Z
dc.date.issued2009-08
dc.identifier.citationHueston, J. L. and Suprenant, K. A. (2009), Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans. Dev. Dyn., 238: 1878–1886. doi:10.1002/dvdy.22007en_US
dc.identifier.urihttp://hdl.handle.net/1808/24463
dc.descriptionThis is the peer reviewed version of the following article: Hueston, J. L. and Suprenant, K. A. (2009), Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans. Dev. Dyn., 238: 1878–1886. doi:10.1002/dvdy.22007, which has been published in final form at http://doi.org/10.1002/dvdy.22007. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.description.abstractEMAP-like proteins (ELPs) are conserved microtubule-binding proteins that function during cell division and in the behavior of post-mitotic cells. In C. elegans, ELP-1 is broadly expressed in many cells and tissues including the touch receptor neurons and body wall muscle. Within muscle, ELP-1 is associated with a microtubule network that is closely opposed to the integrin-based adhesion sites called dense bodies. To examine ELP-1 function we utilized an elp-1 RNA interference assay and screened for synthetic interactions with mutated adhesion site proteins. We reveal a synthetic lethal relationship between ELP-1 and the dystrophin-like protein, DYS-1. Reduction of ELP-1 in a dystrophin [dys-1(cx18)] mutant results in adult animals with motility defects, splayed and hypercontracted muscle with altered cholinergic signaling. Worms fill with vesicles, become flaccid and die. We conclude that ELP-1 is a genetic modifier of a C. elegans model of muscular dystrophy.en_US
dc.publisherWileyen_US
dc.subjectMuscle physiologyen_US
dc.subjectCytoskeletonen_US
dc.subjectCell adhesionen_US
dc.subjectCholinergic agentsen_US
dc.subjectMuscular dystrophyen_US
dc.titleLoss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegansen_US
dc.typeArticleen_US
kusw.kuauthorHueston, Jennifer L.
kusw.kuauthorSuprenant, Kathy A.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1002/dvdy.22007en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2942758en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record