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Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans
dc.contributor.author | Hueston, Jennifer L. | |
dc.contributor.author | Suprenant, Kathy A. | |
dc.date.accessioned | 2017-06-09T17:27:02Z | |
dc.date.available | 2017-06-09T17:27:02Z | |
dc.date.issued | 2009-08 | |
dc.identifier.citation | Hueston, J. L. and Suprenant, K. A. (2009), Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans. Dev. Dyn., 238: 1878–1886. doi:10.1002/dvdy.22007 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24463 | |
dc.description | This is the peer reviewed version of the following article: Hueston, J. L. and Suprenant, K. A. (2009), Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans. Dev. Dyn., 238: 1878–1886. doi:10.1002/dvdy.22007, which has been published in final form at http://doi.org/10.1002/dvdy.22007. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en_US |
dc.description.abstract | EMAP-like proteins (ELPs) are conserved microtubule-binding proteins that function during cell division and in the behavior of post-mitotic cells. In C. elegans, ELP-1 is broadly expressed in many cells and tissues including the touch receptor neurons and body wall muscle. Within muscle, ELP-1 is associated with a microtubule network that is closely opposed to the integrin-based adhesion sites called dense bodies. To examine ELP-1 function we utilized an elp-1 RNA interference assay and screened for synthetic interactions with mutated adhesion site proteins. We reveal a synthetic lethal relationship between ELP-1 and the dystrophin-like protein, DYS-1. Reduction of ELP-1 in a dystrophin [dys-1(cx18)] mutant results in adult animals with motility defects, splayed and hypercontracted muscle with altered cholinergic signaling. Worms fill with vesicles, become flaccid and die. We conclude that ELP-1 is a genetic modifier of a C. elegans model of muscular dystrophy. | en_US |
dc.publisher | Wiley | en_US |
dc.subject | Muscle physiology | en_US |
dc.subject | Cytoskeleton | en_US |
dc.subject | Cell adhesion | en_US |
dc.subject | Cholinergic agents | en_US |
dc.subject | Muscular dystrophy | en_US |
dc.title | Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Hueston, Jennifer L. | |
kusw.kuauthor | Suprenant, Kathy A. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1002/dvdy.22007 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC2942758 | en_US |
dc.rights.accessrights | openAccess |