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Atomic accuracy in predicting and designing non-canonical RNA structure
dc.contributor.author | Das, Rhiju | |
dc.contributor.author | Karanicolas, John | |
dc.contributor.author | Baker, David | |
dc.date.accessioned | 2017-05-11T20:20:43Z | |
dc.date.available | 2017-05-11T20:20:43Z | |
dc.date.issued | 2010-02-28 | |
dc.identifier.citation | Das, Rhiju, John Karanicolas, and David Baker. “Atomic Accuracy in Predicting and Designing Non-Canonical RNA Structure.” Nature methods 7.4 (2010): 291–294. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24111 | |
dc.description.abstract | We present a Rosetta full-atom framework for predicting and designing the non-canonical motifs that define RNA tertiary structure, called FARFAR (Fragment Assembly of RNA with Full Atom Refinement). For a test set of thirty-two 6-to-20-nucleotide motifs, the method recapitulated 50% of the experimental structures at near-atomic accuracy. Additionally, design calculations recovered the native sequence at the majority of RNA residues engaged in non-canonical interactions, and mutations predicted to stabilize a signal recognition particle domain were experimentally validated. | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | https://www.nature.com/nmeth/journal/v7/n4/full/nmeth.1433.html | en_US |
dc.rights | Copyright Nature Publishing Group | en_US |
dc.title | Atomic accuracy in predicting and designing non-canonical RNA structure | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Karanicolas, John | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1038/nmeth.1433 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC2854559 | en_US |
dc.rights.accessrights | openAccess |