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    Atomic accuracy in predicting and designing non-canonical RNA structure

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    karanicolas_atomic.pdf (528.5Kb)
    Issue Date
    2010-02-28
    Author
    Das, Rhiju
    Karanicolas, John
    Baker, David
    Publisher
    Nature Publishing Group
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Published Version
    https://www.nature.com/nmeth/journal/v7/n4/full/nmeth.1433.html
    Rights
    Copyright Nature Publishing Group
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    Abstract
    We present a Rosetta full-atom framework for predicting and designing the non-canonical motifs that define RNA tertiary structure, called FARFAR (Fragment Assembly of RNA with Full Atom Refinement). For a test set of thirty-two 6-to-20-nucleotide motifs, the method recapitulated 50% of the experimental structures at near-atomic accuracy. Additionally, design calculations recovered the native sequence at the majority of RNA residues engaged in non-canonical interactions, and mutations predicted to stabilize a signal recognition particle domain were experimentally validated.
    URI
    http://hdl.handle.net/1808/24111
    DOI
    https://doi.org/10.1038/nmeth.1433
    Collections
    • Molecular Biosciences Scholarly Works [581]
    Citation
    Das, Rhiju, John Karanicolas, and David Baker. “Atomic Accuracy in Predicting and Designing Non-Canonical RNA Structure.” Nature methods 7.4 (2010): 291–294.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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