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Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans

dc.contributor.authorYaegashi, Junko
dc.contributor.authorPraseuth, Mike B.
dc.contributor.authorTyan, Shaiw-Wei
dc.contributor.authorSanchez, James F.
dc.contributor.authorEntwistle, Ruth A.
dc.contributor.authorChiang, Yi-Ming
dc.contributor.authorOakley, Berl R.
dc.contributor.authorWang, Clay C. C.
dc.date.accessioned2017-03-23T18:28:21Z
dc.date.available2017-03-23T18:28:21Z
dc.date.issued2013-06-07
dc.identifier.citationYaegashi, J., Praseuth, M. B., Tyan, S.-W., Sanchez, J. F., Entwistle, R., Chiang, Y.-M., … Wang, C. C. C. (2013). Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans. Organic Letters, 15(11), 2862–2865. http://doi.org/10.1021/ol401187ben_US
dc.identifier.urihttp://hdl.handle.net/1808/23478
dc.description.abstractAspernidine A is a prenylated isoindolinone alkaloid isolated from the model fungus Aspergillus nidulans. A genome-wide kinase knock out library of A. nidulans was examined and it was found that a mitogen-activated protein kinase gene, mpkA, deletion strain produces aspernidine A. Targeted gene deletions were performed in the kinase deletion background to identify the gene cluster for aspernidine A biosynthesis. Intermediates were isolated from mutant strains which provided information about the aspernidine A biosynthesis pathway.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol401187b.en_US
dc.titleMolecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulansen_US
dc.typeArticleen_US
kusw.kuauthorEntwistle, Ruth
kusw.kuauthorOakley, Berl R.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1021/ol401187ben_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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