Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin

Guo, Chun-Jun; Knox, Benjamin P.; Chiang, Yi-Ming; Lo, Hsien-Chun; Sanchez, James F.; Lee, Kuan-Han; Oakley, Berl R.; Bruno, Kenneth S.; Wang, Clay C. C.

dc.contributor.author	Guo, Chun-Jun
dc.contributor.author	Knox, Benjamin P.
dc.contributor.author	Chiang, Yi-Ming
dc.contributor.author	Lo, Hsien-Chun
dc.contributor.author	Sanchez, James F.
dc.contributor.author	Lee, Kuan-Han
dc.contributor.author	Oakley, Berl R.
dc.contributor.author	Bruno, Kenneth S.
dc.contributor.author	Wang, Clay C. C.
dc.date.accessioned	2017-03-23T18:11:32Z
dc.date.available	2017-03-23T18:11:32Z
dc.date.issued	2012-11-16
dc.identifier.citation	Guo, C.-J., Knox, B. P., Chiang, Y.-M., Lo, H.-C., Sanchez, J. F., Lee, K.-H., … Wang, C. C. C. (2012). Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic Letters, 14(22), 5684–5687. http://doi.org/10.1021/ol302682z	en_US
dc.identifier.uri	http://hdl.handle.net/1808/23477
dc.description.abstract	Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.	en_US
dc.publisher	American Chemical Society	en_US
dc.rights	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol302682z..	en_US
dc.title	Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin	en_US
dc.type	Article	en_US
kusw.kuauthor	Oakley, Berl R.
kusw.kudepartment	Molecular Biosciences	en_US
dc.identifier.doi	10.1021/ol302682z	en_US
kusw.oaversion	Scholarly/refereed, author accepted manuscript	en_US
kusw.oapolicy	This item meets KU Open Access policy criteria.	en_US
dc.rights.accessrights	openAccess

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