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Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin
| dc.contributor.author | Guo, Chun-Jun | |
| dc.contributor.author | Knox, Benjamin P. | |
| dc.contributor.author | Chiang, Yi-Ming | |
| dc.contributor.author | Lo, Hsien-Chun | |
| dc.contributor.author | Sanchez, James F. | |
| dc.contributor.author | Lee, Kuan-Han | |
| dc.contributor.author | Oakley, Berl R. | |
| dc.contributor.author | Bruno, Kenneth S. | |
| dc.contributor.author | Wang, Clay C. C. | |
| dc.date.accessioned | 2017-03-23T18:11:32Z | |
| dc.date.available | 2017-03-23T18:11:32Z | |
| dc.date.issued | 2012-11-16 | |
| dc.identifier.citation | Guo, C.-J., Knox, B. P., Chiang, Y.-M., Lo, H.-C., Sanchez, J. F., Lee, K.-H., … Wang, C. C. C. (2012). Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic Letters, 14(22), 5684–5687. http://doi.org/10.1021/ol302682z | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23477 | |
| dc.description.abstract | Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily. | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol302682z.. | en_US |
| dc.title | Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Oakley, Berl R. | |
| kusw.kudepartment | Molecular Biosciences | en_US |
| dc.identifier.doi | 10.1021/ol302682z | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess |
