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γ-Tubulin complexes in microtubule nucleation and beyond
dc.contributor.author | Oakley, Berl R. | |
dc.contributor.author | Paolillo, Vitoria | |
dc.contributor.author | Zheng, Yixian | |
dc.date.accessioned | 2016-12-13T17:13:56Z | |
dc.date.available | 2016-12-13T17:13:56Z | |
dc.date.issued | 2015-07-02 | |
dc.identifier.citation | Oakley, B. R., Paolillo, V., & Zheng, Y. (2015). y-Tubulin complexes in microtubule nucleation and beyond. Molecular Biology of the Cell, 26(17), 2957–2962. doi:10.1091/mbc.e14-11-1514 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22198 | |
dc.description.abstract | Tremendous progress has been made in understanding the functions of γ-tubulin and, in particular, its role in microtubule nucleation since the publication of its discovery in 1989. The structure of γ-tubulin has been determined, and the components of γ-tubulin complexes have been identified. Significant progress in understanding the structure of the γ-tubulin ring complex and its components has led to a persuasive model for how these complexes nucleate microtubule assembly. At the same time, data have accumulated that γ-tubulin has important but less well understood functions that are not simply a consequence of its function in microtubule nucleation. These include roles in the regulation of plus-end microtubule dynamics, gene regulation, and mitotic and cell cycle regulation. Finally, evidence is emerging that γ-tubulin mutations or alterations of γ-tubulin expression play an important role in certain types of cancer and in other diseases. | en_US |
dc.publisher | The American Society For Cell Biology | en_US |
dc.title | γ-Tubulin complexes in microtubule nucleation and beyond | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Oakley, Berl R. | |
kusw.kuauthor | Paolillo, Vitoria | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1091/mbc.E14-11-1514 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |