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dc.contributor.authorOrr, H. Allen
dc.contributor.authorUnckless, Robert L.
dc.date.accessioned2016-08-03T18:00:39Z
dc.date.available2016-08-03T18:00:39Z
dc.date.issued2008-08
dc.identifier.citationH. Allen Orr and Robert L. Unckless , "Population Extinction and the Genetics of Adaptation.," The American Naturalist 172, no. 2 (August 2008): 160-169.en_US
dc.identifier.urihttp://hdl.handle.net/1808/21261
dc.description.abstractTheories of adaptation typically ignore the effect of environmental change on population size. But some environmental challenges—challenges to which populations must adapt—may depress absolute fitness below 1, causing populations to decline. Under this scenario, adaptation is a race; beneficial alleles that adapt a population to the new environment must sweep to high frequency before the population becomes extinct. We derive simple, though approximate, solutions to the probability of successful adaptation (population survival) when adaptation involves new mutations, the standing genetic variation, or a mixture of the two. Our results show that adaptation to such environmental challenges can be difficult when relying on new mutations at one or a few loci, and populations will often decline to extinction.en_US
dc.publisherUniversity of Chicago Pressen_US
dc.subjectAdaptationen_US
dc.subjectBeneficial mutationen_US
dc.subjectExtinctionen_US
dc.subjectProbability of fixationen_US
dc.titlePopulation Extinction and the Genetics of Adaptationen_US
dc.typeArticleen_US
kusw.kuauthorUnckless, Robert L.
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1086/589460en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item does not meet KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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