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dc.contributor.authorQin, Jun
dc.contributor.authorYang, Bo
dc.contributor.authorXu, Bao-Qin
dc.contributor.authorSmithc, Amber
dc.contributor.authorXu, Liang
dc.contributor.authorYuan, Jian-Lin
dc.contributor.authorLi, Ling
dc.date.accessioned2015-12-29T17:14:08Z
dc.date.available2015-12-29T17:14:08Z
dc.date.issued2014
dc.identifier.citationQin et. al. "Concurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survival." International Journal of Clinical and Experimental Pathology (2014): v7(6). www.ijcep.comen_US
dc.identifier.urihttp://hdl.handle.net/1808/19336
dc.descriptionThis is the published version.en_US
dc.description.abstractAlthough CD44 was overexpressed and considered as a useful prognostic marker in renal cell carcinoma, the prognostic role of CD44s in clear cell renal cell carcinoma (ccRCC) remains controversial. Moreover, the correlation and prognostic significance of CD44s and its downstream signaling target pSTAT3 are unclear in ccRCC. In this study, 75 pairs of carcinoma and paired adjacent non-tumor renal tissue samples were collected from patients with localized ccRCC who underwent a nephrectomy. The expression levels of CD44s and pSTAT3 were analyzed using immunohistochemistry. Correlations between CD44s/pSTAT3 expression and clinical and pathological characteristics were determined using x2 test, Kaplan-Meier analysis and Cox’s proportional hazards model. We found that CD44s is highly expressed in 46.67% of tumor tissues, and its high expression was significantly associated with high tumor grade (P < 0.001), large tumor size (P = 0.009) and advanced T stage (P = 0.004). A strong correlation exists between high expression of CD44s and pSTAT3 (r = 0.4013, P = 0.0004). The joint over expression of CD44s and pSTAT3 was present in 42.66% of tumor specimens and had an additive negative impact on overall survival. Patients with CD44shighpSTAT3high expression had significantly poor survival as compared to patients with CD44slowpSTAT3low tumor expression (P = 0.024), though the concurrent overexpression of CD44s and pSTAT3 was not an independent prognostic factor for overall survival. Our data indicate that expression of both CD44s and pSTAT3 in ccRCC is associated with advanced tumor stage and patient survival. The conclusions from this study may improve the prediction of ccRCC prognosis information when CD44s and pSTAT3 expression are evaluated together with classical clinicopathological parameters.en_US
dc.publishere-Century Publishingen_US
dc.relation.isversionofhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097256/en_US
dc.subjectCD44sen_US
dc.subjectpSTAT3en_US
dc.subjectccRCCen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.titleConcurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survivalen_US
dc.typeArticle
kusw.kuauthorXu, Liang
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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