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Research Centers: Recent submissions
Now showing items 101-120 of 241
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Vaccination With Mouse Dendritic Cells Loaded With an IpaD-IpaB Fusion Provides Protection Against Shigellosis
(Frontiers Media, 2019-02-08)Diarrheal diseases are a major cause of morbidity and mortality worldwide. They are most prevalent in settings with inadequate sanitation, poor hygiene and contaminated water. An important diarrheal pathogen in such settings ... -
Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors
(MDPI, 2019-02-25)Proteases are a major enzyme group playing important roles in a wide variety of biological processes in life forms ranging from viruses to mammalians. The aberrant activity of proteases can lead to various diseases; ... -
Synchrony is more than its top-down and climatic parts: Interacting Moran effects on phytoplankton in British seas
(Public Library of Science, 2019-03-28)Large-scale spatial synchrony is ubiquitous in ecology. We examined 56 years of data representing chlorophyll density in 26 areas in British seas monitored by the Continuous Plankton Recorder survey. We used wavelet methods ... -
Quantitative Genetic Mapping and Genome Assembly in the Lesser Wax Moth Achroia grisella
(Genetics Society of America, 2019-05-17)Specific characteristics of the male Achroia grisella acoustic mating signal determine a male’s attractiveness toward females. These features are genetically variable in populations, and mapping experiments have been used ... -
Timing of Early-Life Stress and the Development of Brain-Related Capacities
(Frontiers Media, 2019-08-06)Early-life stress (ELS) poses risks for developmental and mental health problems throughout the lifespan. More research is needed regarding how specific ELS experiences influence specific aspects of neurodevelopment. We ... -
Self‐organizing cicada choruses respond to the local sound and light environment
(Wiley Open Access, 2020-04-20)1. Periodical cicadas exhibit an extraordinary capacity for self‐organizing spatially synchronous breeding behavior. The regular emergence of periodical cicada broods across the United States is a phenomenon of longstanding ... -
Effects of the soil microbiome on the demography of two annual prairie plants
(Wiley Open Access, 2020-06-14)1. Both mutualistic and pathogenic soil microbes are known to play important roles in shaping the fitness of plants, likely affecting plants at different life cycle stages. 2. In order to investigate the differential ... -
Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases
(Frontiers Media, 2020-06-23)As β-lactams are reconsidered for the treatment of tuberculosis (TB), their targets are assumed to be peptidoglycan transpeptidases, as verified by adduct formation and kinetic inhibition of Mycobacterium tuberculosis (Mtb) ... -
Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction
(Wiley, 2020-08-08)RNA-binding protein Musashi-1 (MSI1) is a key regulator of several stem cell populations. MSI1 is involved in tumor proliferation and maintenance, and it regulates target mRNAs at the translational level. The known mRNA ... -
Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts
(American Chemical Society, 2019-07-02)Integrin αIIbβ3, a transmembrane heterodimer, mediates platelet aggregation when it switches from an inactive to an active ligand-binding conformation following platelet stimulation. Central to regulating αIIbβ3 activity ... -
Abiotic and biotic context dependency of perennial crop yield
(Public Library of Science, 2020-06-26)Perennial crops in agricultural systems can increase sustainability and the magnitude of ecosystem services, but yield may depend upon biotic context, including soil mutualists, pathogens and cropping diversity. These ... -
Frequent fire slows microbial decomposition of newly deposited fine fuels in a pyrophilic ecosystem
(Springer Nature, 2020-07-22)Frequent fires maintain nearly 50% of terrestrial ecosystems, and drive ecosystem changes that govern future fires. Since fires are dependent on available plant or fine fuels, ecosystem processes that alter fine fuel loads ... -
Cooperativity in Proteasome Core Particle Maturation
(Elsevier, 2020-04-22)Proteasomes are multi-subunit protease complexes found in all domains of life. The maturation of the core particle (CP), which harbors the active sites, involves dimerization of two half CPs (HPs) and an autocatalytic ... -
AI Radar Sensor: Creating Radar Depth Sounder Images Based on Generative Adversarial Network
(2019-12-12)Significant resources have been spent in collecting and storing large and heterogeneous radar datasets during expensive Arctic and Antarctic fieldwork. The vast majority of data available is unlabeled, and the labeling ... -
Leaf litter identity alters the timing of lotic nutrient dynamics
(Wiley, 2019-09-30)1. The effects of resource quality on ecosystems can shift through time based on preferential use and elemental needs of biotic consumers. For example, leaf litter decomposition rates are strongly controlled by initial ... -
Low-level dissolved organic carbon subsidies drive a trophic upsurge in a boreal stream
(Wiley, 2020-01-13)1. Energy pathways in stream food webs are often driven by allochthonous basal resources. However, allochthonous dissolved organic carbon (DOC) is generally viewed as a minor if not insignificant basal resource because ... -
Computing the Dynamic Supramolecular Structural Proteome
(Public Library of Science, 2017-01-19) -
Spatiotemporal predictions of soil properties and states in variably saturated landscapes
(American Geophysical Union, 2017-06-19)Understanding greenhouse gas (GHG) fluxes from landscapes with variably saturated soil conditions is challenging given the highly dynamic nature of GHG fluxes in both space and time, dubbed hot spots, and hot moments. On ... -
Intercomparison of snow depth retrievals over Arctic sea ice from radar data acquired by Operation IceBridge
(European Geosciences Union, 2017-11)Since 2009, the ultra-wideband snow radar on Operation IceBridge (OIB; a NASA airborne mission to survey the polar ice covers) has acquired data in annual campaigns conducted during the Arctic and Antarctic springs. ... -
Radar sounder evidence of thick, porous sediments in Meridiani Planum and implications for ice‐filled deposits on Mars
(American Geophysical Union, 2017-09-19)Meridiani Planum is one of the most intensely studied regions on Mars, yet little is known about the physical properties of the deposits below those examined by the Opportunity rover. We report the detection of subsurface ...
