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Research Centers: Recent submissions
Now showing items 121-140 of 241
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Soy moratorium impacts on soybean and deforestation dynamics in Mato Grosso, Brazil
(Public Library of Science, 2017-04-28)Previous research has established the usefulness of remotely sensed vegetation index (VI) data from the Moderate Resolution Imaging Spectroradiometer (MODIS) to characterize the spatial dynamics of agriculture in the ... -
Nomenclatural novelties and notes in Penstemon (Plantaginaceae)
(Pensoft Publishers, 2017-04-25)Seven nomenclatural novelties in Penstemon (Plantaginaceae) are proposed for taxa that will be included in the forthcoming treatment of the genus in the Flora of North America North of Mexico series. Three additional ... -
Crosstalk and the evolvability of intracellular communication
(Nature Research, 2017-07-10)Metazoan signalling networks are complex, with extensive crosstalk between pathways. It is unclear what pressures drove the evolution of this architecture. We explore the hypothesis that crosstalk allows different cell ... -
Fundamental trade-offs between information flow in single cells and cellular populations
(National Academy of Sciences, 2017-05)Signal transduction networks allow eukaryotic cells to make decisions based on information about intracellular state and the environment. Biochemical noise significantly diminishes the fidelity of signaling: networks ... -
Lineage space and the propensity of bacterial cells to undergo growth transitions
(Public Library of Science, 2018-08-22)The molecular makeup of the offspring of a dividing cell gradually becomes phenotypically decorrelated from the parent cell by noise and regulatory mechanisms that amplify phenotypic heterogeneity. Such regulatory mechanisms ... -
Cooperative p16 and p21 action protects female astrocytes from transformation
(BioMed Central, 2018-02-20)Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism in retinoblastoma ... -
Astrocytes Attenuate Mitochondrial Dysfunctions in Human Dopaminergic Neurons Derived from iPSC
(Elsevier, 2018-01-27)Astrocytes, the most populous glial cell type in the brain, are critical for regulating the brain microenvironment. In various neurodegenerative diseases, astrocytes determine the progression and outcome of the neuropathological ... -
Natural language processing in text mining for structural modeling of protein complexes
(BioMed Central, 2018-03-05)BACKGROUND: Structural modeling of protein-protein interactions produces a large number of putative configurations of the protein complexes. Identification of the near-native models among them is a serious challenge. ... -
Early Probe and Drug Discovery in Academia: A Minireview
(MDPI, 2018-02-09)Drug discovery encompasses processes ranging from target selection and validation to the selection of a development candidate. While comprehensive drug discovery work flows are implemented predominantly in the big pharma ... -
Comparative oncology approach to drug repurposing in osteosarcoma
(Public Library of Science, 2018-03-26)BACKGROUND: Osteosarcoma is an orphan disease for which little improvement in survival has been made since the late 1980s. New drug discovery for orphan diseases is limited by the cost and time it takes to develop new ... -
Mitochondrial Dysfunction Triggers Synaptic Deficits via Activation of p38 MAP Kinase Signaling in Differentiated Alzheimer’s Disease Trans-Mitochondrial Cybrid Cells
(IOS Press, 2017-07-03)Loss of synapse and synaptic dysfunction contribute importantly to cognitive impairment in Alzheimer’s disease (AD). Mitochondrial dysfunction and oxidative stress are early pathological features in AD-affected brain. ... -
Mitochondrial Perturbation in Alzheimer’s Disease and Diabetes
(Elsevier, 2017-02-04)Mitochondria are well-known cellular organelles that play a vital role in cellular bioenergetics, heme biosynthesis, thermogenesis, calcium homeostasis, lipid catabolism, and other metabolic activities. Given the extensive ... -
Development of High-Throughput Screening Assay for Antihantaviral Therapeutics
(SAGE Publications, 2017-07)Humans acquire hantavirus infection by the inhalation of aerosolized excreta of infected rodent hosts. There is no treatment for hantavirus diseases at present. Therapeutic intervention during early stages of viral infection ... -
Measuring and statistically testing the size of the effect of a chemical compound on a continuous in-vitro pharmacological response through a new statistical model of response detection limit
(Taylor & Francis, 2015)Biomolecular screening research frequently searches for the chemical compounds that are most likely to make a biochemical or cell-based assay system produce a strong continuous response. Several doses are tested with each ... -
Mathematical Model for Length Control by the Timing of Substrate Switching in the Type III Secretion System
(Public Library of Science, 2016-04)Type III Secretion Systems (T3SS) are complex bacterial structures that provide gram-negative pathogens with a unique virulence mechanism whereby they grow a needle-like structure in order to inject bacterial effector ... -
Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes
(Springer Verlag, 2016-08)The excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2), mostly located on astrocytes, are the main mediators for glutamate clearance in humans. Malfunctions of these transporters may lead to excessive glutamate ... -
Oxaloacetate Enhances Neuronal Cell Bioenergetic Fluxes and Infrastructure
(Wiley, 2016-03-11)We tested how the addition of oxaloacetate (OAA) to SH-SY5Y cells affected bioenergetic fluxes and infrastructure, and compared the effects of OAA to malate, pyruvate, and glucose deprivation. OAA displayed pro-glycolysis ... -
Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice
(Elsevier, 2009-04)Our previous studies have demonstrated that mice with reduced or absent serotonin transporter (SERT+/− and SERT−/− mice, respectively) are more sensitive to stress relative to their SERT normal littermates (SERT+/+ mice). ... -
Head-group acylation of monogalactosyldiacylglycerol is a common stress response, and the acyl-galactose acyl composition varies with the plant species and applied stress
(Wiley, 2014-04)Formation of galactose-acylated monogalactosyldiacylglycerols has been shown to be induced by leaf homogenization, mechanical wounding, avirulent bacterial infection, and thawing after snap-freezing. Here, lipidomic analysis ... -
Metabolism Changes During Aging in the Hippocampus and Striatum of Glud1 (Glutamate Dehydrogenase 1) Transgenic Mice
(Springer Verlag, 2014)The decline in neuronal function during aging may result from increases in extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered mitochondrial metabolism. To study metabolic responses to persistently high ...