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KU Med Center Dissertations and Theses: Recent submissions
Now showing items 141-160 of 464
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CELLULAR PATHWAY DEREGULATION AND POTENTIAL TARGETED THERAPY FOR ADULT T-CELL LEUKEMIA
(University of Kansas, 2017-12-31)Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of Adult T-cell Leukemia (ATL), a lymphoproliferative disorder with a very poor prognosis. While approximatively 5% of individuals infected with HTLV-1 ... -
MODULES OF THE SAGA CHROMATIN-MODIFYING COMPLEX PLAY DISTINCT ROLES IN DROSOPHILA GENE EXPRESSION AND DEVELOPMENT
(University of Kansas, 2017-12-31)Histone modifications are an important component of epigenetic control. Histone modifying enzymes are often integrated into large multi-subunit complexes. The Spt-Ada-Gcn5-acetyltransferase (SAGA) chromatin-modifying complex ... -
Novel Statistical Methodology Development and Applications in ALS Research
(University of Kansas, 2017-12-31)Being able to predict, with accuracy, the disease progression of patients with a given disease is extremely useful from the perspectives of clinicians, patients, and clinical trial investigators. We introduce a novel method ... -
PERCEPTIONS AND EXPERIENCES OF BACCALAUREATE NURSING PROGRAM LEADERS RELATED TO NURSING INFORMATICS
(University of Kansas, 2017-12-31)Nursing program leadership for integrating nursing informatics (NI) into curricula is essential. NI is a specialty that combines nursing science, computer science, and information science to manage health information and ... -
The Relationship of Nurse Staffing in Acute Care Hospitals on 30-Day Readmissions in an Era of Pay for Performance
(University of Kansas, 2017-12-31)Provisions of the 2010 Affordable Care Act have placed hospitals in the center of financial accountability for reducing readmissions on key conditions and have heightened interest in identifying system-level interventions ... -
Aerobic Capacity and Bile Acid Metabolism
(University of Kansas, 2017-12-31)High aerobic capacity is strongly correlated to protection from a wide range of metabolic diseases. Bile acids are now recognized as potential players in protection against metabolic disease. We tested the hypothesis that ... -
Faculty Descriptions of the Student Preparation Phase in Undergraduate Nursing Simulation: A Qualitative Descriptive Study
(University of Kansas, 2017-05-31)Simulation is being used for clinical experiences in many undergraduate nursing programs across the United States. With the widespread use of simulation, best-practices for design and implementation are important for faculty ... -
Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids
(University of Kansas, 2017-05-31)Uterine fibroids, also known as leiomyomas, are benign smooth muscle cell (SMC) tumors of the myometrium and are the most frequent reason for a hysterectomy. Although benign, these tumors pose a significant burden on ... -
Implementation of a Quality Improvement Initiative to Optimize Testing and Improve Antibiotic Utilization for Group A Streptococcal Pharyngitis in a Community Pediatric Practice
(University of Kansas, 2017-05-31)Background and Objective: Acute pharyngitis is a common diagnosis in ambulatory pediatrics. The Infectious Diseases Society of America (IDSA) clinical practice guideline for group A streptococcal (GAS) pharyngitis recommends ... -
A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
(University of Kansas, 2017-05-31)Uterine Leiomyoma (UL), also known as Uterine Fibroids, are benign, hormone-sensitive tumors arising in the smooth muscle tissue layer of the uterus, the myometrium. UL are the most common female reproductive tract tumors, ... -
Neonatal maternal separation in mice as a pre-clinical model for male chronic pelvic pain and voluntary exercise interventions
(University of Kansas, 2017-05-31)Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is frequently co-diagnosed with other functional pain disorders, most significantly interstitial cystitis/painful bladder syndrome (IC/PBS), as well as mood ... -
Identification of licofelone through three-dimensional cell culture drug screening as a repurposed agent able to reverse drug resistant and cancer stem cell-like subpopulations in ovarian cancer
(University of Kansas, 2017-05-31)Since the introduction of paclitaxel in 1992, the overall survival for women diagnosed with ovarian cancer has remained relatively stagnant. This unsatisfactory outcome is in part attributed to the presence of subpopulations ... -
Perceptions, adequacy, and acquisition of clinical advanced practice training and skills in the dietetic profession
(University of Kansas, 2017-08-31)Purpose: This study aimed to investigate RDN use of nutrition-related lab testing as a potential advanced clinical skill, and to describe RDN perceptions of the adequacy of training for nutrition-related lab testing and ... -
Tobacco Cessation: A Quality Improvement Project Using the 5 A’s Model
(University of Kansas, 2017-12-31)TOBACCO CESSATION: A QUALITY IMPROVEMENT PROJECT USING THE 5 A’S MODEL Background: Tobacco use remains the leading preventable cause of death, disease, and disability in the United States. Current statistics show that ... -
Circulating Adipose Stromal Cells (CASCs) as a Potential Biomarker of Response to Weight Loss Interventions in Obese Women at High Risk for Breast Cancer
(University of Kansas, 2017-05-31)Background. Obesity is a modifiable risk factor for breast cancer in the United States. White adipose tissue is increased in obese (BMI ≥ 30 kg/m2) women and the dysfunction resulting from adipocyte hyperplasia and hypertrophy ... -
Drosophila CPEB, Orb2, a Putative Biochemical Engram of Long-term Memory
(University of Kansas, 2017-08-31)How a transient experience creates an enduring yet dynamic memory remains a fundamental unresolved issue in studies of memory. Experience-dependent aggregation of the RNA-binding protein CPEB/Orb2 is one of the candidate ... -
THE ROLE OF MATRICELLULAR SIGNALING IN POLYCYSTIC KIDNEY DISEASE
(University of Kansas, 2017-08-31)Polycystic kidney disease (PKD) is characterized by excessive enlargement of the kidney, due to the hyperplastic growth of renal epithelial cells, giving rise to fluid-filled cysts. Autosomal dominant PKD (ADPKD), the most ... -
EFFECTS OF SENSORY PROCESSING PATTERNS ON SOCIAL SKILLS AND PROBLEM BEHAVIORS
(University of Kansas, 2017-08-31)Abstract Sensory processing affects daily life activities including social participation. Numerous research studies have examined the effects of sensory processing on socialization in children with conditions, while limited ... -
The effect of protein deficiency on the hemopoietic organs and the blood of the albino rat
(University of Kansas, 1951)