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  An experimental analysis of the motor cell columns in the cervical enlargement of the spinal cord in the albino rat 

  Goering, Joseph H. (University of Kansas, 1927-05-31)
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  Measuring Individual Treatment Benefits Using Longitudinal Outcomes from Clinical Trials or Hospital Data 

  ZHANG, XUAN (University of Kansas, 2019-12-31)

  It is increasingly recognized that a patient’s response to a medical treatment is a statistically heterogeneous phenomenon. The average treatment effects may not represent a heterogeneous population of patients. The benefits ...
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  A new role for NKG2D signaling in CD8+ T cells and autoimmune diabetes 

  Trembath, Andrew Peter (University of Kansas, 2019-12-31)

  The demands placed on the immune system are immense and highly complex. It must protect the body against untold threats while maintaining a balance between immune defense and autoimmune damage. One major player in immune ...
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  Novel Statistical Methods for Missing Data and Multiplicity in Alzheimer’s Research 

  Montgomery, Robert (University of Kansas, 2019-12-31)

  The application of statistical procedures to real data sets seldom proceeds as seamlessly as a textbook problem where all assumptions are verified, and sample sizes are adequate. Common issues include lack of adherence to ...
• Prediction of random effects in mixed effects models under violations of the normality assumption for the random-effects and a graphical approach to detect violations 

  Wang, Zhiwen (University of Kansas, 2019-12-31)

  In longitudinal data analysis, the introduction of random effects provides statisticians with a convenient tool for modeling repeated measurements. Mixed effects linear models extend linear and generalized linear models ...
• Statistical Evaluation of Drug Safety in Clinical Trials 

  Duan, Jiawei (University of Kansas, 2019-12-31)

  The evaluation of drug safety is critically important in clinical trials. The first part of this dissertation explores new statistical methods for drug safety signal detection in two-arm clinical trials. Current statistical ...
• Learning about Techniques to Create Healthy Infants through Nutrition and Proper Growth: The LATCHING Pilot Project 

  Cauble, Jennifer S (University of Kansas, 2019-12-31)

  Abstract Background: Despite numerous benefits for both mom and baby, early cessation of breastfeeding and introduction of solids is common. Interventions to improve breastfeeding rates and prevent the early introduction ...
• Topics in Goodness-of-fit Test for Logistic Regression Models with Continuous Covariates 

  Lu, Pengcheng (University of Kansas, 2019-05-31)

  There is no phenomenal method practitioners can use as a appropriate tool for model validation when sparse data are presented in multiple logistic regression models. The characteristics of sparsity, i.e. very few number ...
• Assessing the Relationship Between Prenatal DHA Status on Offspring Body Composition 

  Horton, Sarah (University of Kansas, 2019-05-31)

  ABSTRACT Background: As childhood obesity rates continue to rise, it is crucial to discover more effective prevention strategies. Most obesity prevention treatment strategies are implemented in school-age children. However, ...
• The influence of diet and exercise on early life stress-induced co-morbid disorders in mice 

  Eller-Smith, Olivia Catherine (University of Kansas, 2019-05-31)

  Individuals with functional pain disorders often present with symptoms of or are diagnosed with more than one disorder. Furthermore, these patients with co-morbid pain disorders are also more likely to present with mood ...
• Prediction Models for Cancer Risk and Prognosis using Clinical and DNA Methylation Biomarkers: Considerations in Study Design and Model Development 

  Graw, Stefan Hannes (University of Kansas, 2019-05-31)

  The ability to accurately predict the prognosis for any given disease is of immense value for clinicians and patients. It can dictate and optimize an individual treatment plan for a patient and ultimately improve their ...
• Examining Enrollment Barriers to Adult Cancer Clinical Trials 

  Mackay, Christine (University of Kansas, 2019-05-31)

  Advancing knowledge in cancer treatment can only be achieved with the conduct of clinical trials. Barriers to adult cancer clinical trial participation have been extensively examined, yet nearly 20% of trials fail due to ...
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  Role of primary cilia-mediated signaling in human and mouse models of Autosomal Dominant Polycystic Kidney Disease 

  Silva, Luciane M (University of Kansas, 2018-12-31)

  Primary cilia are non-motile microtubule-based organelles that extend from the apical plasma membrane of most vertebrate cells and mediate signaling pathways. Mutations in ciliary genes often result in renal cyst formation, ...
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  CHARACTERIZATION OF THE MAMMALIAN METHYLTRANSFERASE TGS1 

  Chen, Li (University of Kansas, 2018-08-31)

  In eukaryotes, RNAs transcribed by RNA polymerase II are capped at their 5’ end. The cap is added co-transcriptionally and, in the case of mRNAs, contains one methyl group, resulting in a monomethylguanosine cap. In the ...
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  Regulated assembly of a prion-like phosphatase, CG5830, controls its phosphatase activity and embryonic development in Drosophila melanogaster 

  Nil, Zelha (University of Kansas, 2018-08-31)

  Prion-like proteins can assume distinct conformational states in the same cell, and often one of these states leads to a self-assembling oligomer that can vary in physical nature. The conformational state change from ...
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  Characterization of SPECC1L Function in Palatogenesis 

  Hall, Everett Gordon (University of Kansas, 2019-05-31)

  Orofacial clefts are among the most common congenital birth defects, occurring in as many as 1 in 800 births worldwide. Genetic and environmental factors contribute to the complex etiology of these anomalies. SPECC1L encodes ...
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  EXPRESSION PATTERNS AND ROLES OF THE IKAROS FAMILY OF TRANSCRIPTION FACTORS IN HUMAN REGULATORY T CELL DEVELOPMENT AND FUNCTION. 

  Seng, Amara (University of Kansas, 2019-05-31)

  Regulatory T cells (Tregs) are a small subset of immune cells that are responsible for downregulating the immune response and maintaining immune tolerance. Tregs are generally defined by a high expression of the transcription ...
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  A Combination of Three Synthetic Compounds Display Potent Antitumor Effects 

  Arnold, Levi Kent (University of Kansas, 2018-12-31)

  Patients suffering from head and neck squamous cell carcinoma (HNSCC) encounter low survival while managing current aggressive therapies that cause significant morbidity. Nutraceuticals are diet-derived compounds with few ...
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  The role of claudin-2 in the proximal tubule and kidney stone disease 

  Curry, Joshua Nicholas (University of Kansas, 2018-08-31)

  The concentration of circulating blood calcium is vital to the function of many cellular processes. As such, it is maintained within a narrow range through the actions of gastrointestinal, bone, kidney, and endocrine ...
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  The Relationship Between Diet, Body Composition, Cardiorespiratory Fitness and Respiratory Quotient 

  Bouchard, Isabelle Mariah (University of Kansas, 2019-05-31)

  Background: Respiratory Quotient (RQ) indicates the oxidation of fat or carbohydrate as a fuel source for the body during energy expenditure. Resting Metabolic Rate (RMR) and RQ are often determined during the same metabolic ...

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