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    CELLULAR PATHWAY DEREGULATION AND POTENTIAL TARGETED THERAPY FOR ADULT T-CELL LEUKEMIA

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    Moles_ku_0099D_15637_DATA_1.pdf (5.147Mb)
    Issue Date
    2017-12-31
    Author
    Moles, Ramona
    Publisher
    University of Kansas
    Format
    344 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Pathology & Laboratory Medicine
    Rights
    Copyright held by the author.
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    Abstract
    Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of Adult T-cell Leukemia (ATL), a lymphoproliferative disorder with a very poor prognosis. While approximatively 5% of individuals infected with HTLV-1 develop ATL within twenty years of first infection, the molecular mechanism that the virus uses to induce ATL is not entirely understood. microRNAs are posttranscriptional regulators involved in a wide range of biological processes. Based on biological functions, alteration of their expression can potentially contribute to tumor initiation and progression. The purpose of this thesis is to study changes in miRNA expression and their role in the deregulation of cellular pathways essential in HTLV-1-transformed and ATL cells. Moreover, the absence of an effective treatment for patients led to investigation of potential therapeutic strategies for ATL. Since previous findings show that DNA repair is impaired in HTLV-1-transformed cells, this thesis is focused on targeting DNA repair as a new therapeutic option in ATL. More specifically, the aim is the study of antiproliferative effects and cytotoxicity of PARP and helicase inhibitors in HTLV-1-transformed and ATL cells.
    URI
    http://hdl.handle.net/1808/27030
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    • Dissertations [4454]
    • KU Med Center Dissertations and Theses [464]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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