dc.contributor.author | Vakser, Ilya A. | |
dc.date.accessioned | 2015-05-05T20:42:48Z | |
dc.date.available | 2015-05-05T20:42:48Z | |
dc.date.issued | 1996-09-01 | |
dc.identifier.citation | Vakser, I. (1996). Main-chain complementarity in protein-protein recognition. "Protein Engineering, Design and Selection", 9(9), 741-744. http://www.dx.doi.org/10.1093/protein/9.9.741 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/17602 | |
dc.description | This is the publisher's version, also available electronically from "http://peds.oxfordjournals.org". | en_US |
dc.description.abstract | We present a statistical analysis of protein structures based on interatomic Ca distances. The overall distance distributions reflect in detail the contents of sequence-specific substructures maintained by local interactions (such as α-helixes) and longer range interactions (such as disulfide bridges and β-sheets). We also show that a volume scaling of the distances makes distance distributions for protein chains of different length superimposable. Distance distributions were also calculated specifically for amino acids separated by a given number of residues. Specific features in these distributions are visible for sequence separations of up to 20 amino acid residues. A simple representation, which preserves most of the information in the distance distributions, was obtained using six parameters only. The parameters give rise to canonical distance intervals and when predicting coarse-grained distance constraints by methods such as data-driven artificial neural networks, these should preferably be selected from these intervals. We discuss the use of the six parameters for determining or reconstructing 3-D protein structures. | en_US |
dc.publisher | Oxford University Press | en_US |
dc.title | Main-chain complementarity in protein-protein recognition | en_US |
dc.type | Article | |
kusw.kuauthor | Vakser, Ilya A. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1093/protein/9.9.741 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess | |