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dc.contributor.authorVakser, Ilya A.
dc.date.accessioned2015-05-05T20:42:48Z
dc.date.available2015-05-05T20:42:48Z
dc.date.issued1996-09-01
dc.identifier.citationVakser, I. (1996). Main-chain complementarity in protein-protein recognition. "Protein Engineering, Design and Selection", 9(9), 741-744. http://www.dx.doi.org/10.1093/protein/9.9.741en_US
dc.identifier.urihttp://hdl.handle.net/1808/17602
dc.descriptionThis is the publisher's version, also available electronically from "http://peds.oxfordjournals.org".en_US
dc.description.abstractWe present a statistical analysis of protein structures based on interatomic Ca distances. The overall distance distributions reflect in detail the contents of sequence-specific substructures maintained by local interactions (such as α-helixes) and longer range interactions (such as disulfide bridges and β-sheets). We also show that a volume scaling of the distances makes distance distributions for protein chains of different length superimposable. Distance distributions were also calculated specifically for amino acids separated by a given number of residues. Specific features in these distributions are visible for sequence separations of up to 20 amino acid residues. A simple representation, which preserves most of the information in the distance distributions, was obtained using six parameters only. The parameters give rise to canonical distance intervals and when predicting coarse-grained distance constraints by methods such as data-driven artificial neural networks, these should preferably be selected from these intervals. We discuss the use of the six parameters for determining or reconstructing 3-D protein structures.en_US
dc.publisherOxford University Pressen_US
dc.titleMain-chain complementarity in protein-protein recognitionen_US
dc.typeArticle
kusw.kuauthorVakser, Ilya A.
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oanotesPer SHERPA/RoMEO 5/5/2015: Pre-print can only be posted prior to acceptance Pre-print must be accompanied by set statement (see link) Pre-print must not be replaced with post-print, instead a link to published version with amended set statement should be made Post-print in Institutional repositories or Central repositories Publisher version cannot be used Published source must be acknowledged Must link to publisher version Set phrase to accompany archived copy (see policy) Eligible authors may deposit in OpenDepot The publisher will deposit in PubMed Central on behalf of NIH authorsen_US
dc.identifier.doi10.1093/protein/9.9.741
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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