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    Main-chain complementarity in protein-protein recognition

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    VakserI_PE_9(9)741.pdf (4.084Mb)
    Issue Date
    1996-09-01
    Author
    Vakser, Ilya A.
    Publisher
    Oxford University Press
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    We present a statistical analysis of protein structures based on interatomic Ca distances. The overall distance distributions reflect in detail the contents of sequence-specific substructures maintained by local interactions (such as α-helixes) and longer range interactions (such as disulfide bridges and β-sheets). We also show that a volume scaling of the distances makes distance distributions for protein chains of different length superimposable. Distance distributions were also calculated specifically for amino acids separated by a given number of residues. Specific features in these distributions are visible for sequence separations of up to 20 amino acid residues. A simple representation, which preserves most of the information in the distance distributions, was obtained using six parameters only. The parameters give rise to canonical distance intervals and when predicting coarse-grained distance constraints by methods such as data-driven artificial neural networks, these should preferably be selected from these intervals. We discuss the use of the six parameters for determining or reconstructing 3-D protein structures.
    Description
    This is the publisher's version, also available electronically from "http://peds.oxfordjournals.org".
    URI
    http://hdl.handle.net/1808/17602
    DOI
    https://doi.org/10.1093/protein/9.9.741
    Collections
    • Molecular Biosciences Scholarly Works [598]
    Citation
    Vakser, I. (1996). Main-chain complementarity in protein-protein recognition. "Protein Engineering, Design and Selection", 9(9), 741-744. http://www.dx.doi.org/10.1093/protein/9.9.741

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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