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Structure of Agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit
dc.contributor.author | Tang, Liang | |
dc.contributor.author | Zhou, Yuan-Cong | |
dc.contributor.author | Lin, Zheng-jiong | |
dc.date.accessioned | 2015-05-05T19:26:24Z | |
dc.date.available | 2015-05-05T19:26:24Z | |
dc.date.issued | 1999-12-01 | |
dc.identifier.citation | Tang, L., Zhou, Y., & Lin, Z. (1999). Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit. Acta Crystallographica Section D Biological Crystallography, 55(12), 1986-1996. http://www.dx.doi.org/10.1107/S0907444999012603 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/17593 | |
dc.description | This is the publisher's version, also available electronically from "http://scripts.iucr.org". | en_US |
dc.description.abstract | The structure of agkistrodotoxin crystallized under basic conditions has been determined at 2.8 Å resolution by the molecular-replacement technique and refined to a crystallographic R factor of 0.194 and a free R factor of 0.260 with good stereochemistry. The molecular packing in the crystal differs from other PLA2s. The six molecules in the asymmetric unit form three dimers linked by Ca2+ ions in a near-perfect six-ligand octahedral coordinating system. Extensive intermolecular hydrophobic interactions occur at the interfacial recognition site of each neurotoxin molecule, which provides an insight into phospholipase A2-membrane interactions. This hydrophobic interaction-induced molecular association along the interfacial recognition site suggests a self-protection mechanism of agkistrodotoxin. | en_US |
dc.publisher | International Union of Crystallography | en_US |
dc.subject | agkistrodotoxin | en_US |
dc.subject | Molecular replacement | en_US |
dc.subject | Calcium ions | en_US |
dc.subject | hydrophobic interaction | en_US |
dc.subject | Neurotoxic site | en_US |
dc.subject | phospholipase A2 | en_US |
dc.subject | presynaptic neurotoxin | en_US |
dc.title | Structure of Agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit | en_US |
dc.type | Article | |
kusw.kuauthor | Tang, Liang | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1107/S0907444999012603 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |