Show simple item record

dc.contributor.authorTang, Liang
dc.contributor.authorZhou, Yuan-Cong
dc.contributor.authorLin, Zheng-jiong
dc.date.accessioned2015-05-05T19:26:24Z
dc.date.available2015-05-05T19:26:24Z
dc.date.issued1999-12-01
dc.identifier.citationTang, L., Zhou, Y., & Lin, Z. (1999). Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit. Acta Crystallographica Section D Biological Crystallography, 55(12), 1986-1996. http://www.dx.doi.org/10.1107/S0907444999012603en_US
dc.identifier.urihttp://hdl.handle.net/1808/17593
dc.descriptionThis is the publisher's version, also available electronically from "http://scripts.iucr.org".en_US
dc.description.abstractThe structure of agkistrodotoxin crystallized under basic conditions has been determined at 2.8 Å resolution by the molecular-replacement technique and refined to a crystallographic R factor of 0.194 and a free R factor of 0.260 with good stereochemistry. The molecular packing in the crystal differs from other PLA2s. The six molecules in the asymmetric unit form three dimers linked by Ca2+ ions in a near-perfect six-ligand octahedral coordinating system. Extensive intermolecular hydrophobic interactions occur at the interfacial recognition site of each neurotoxin molecule, which provides an insight into phospholipase A2-membrane interactions. This hydrophobic interaction-induced molecular association along the interfacial recognition site suggests a self-protection mechanism of agkistrodotoxin.en_US
dc.publisherInternational Union of Crystallographyen_US
dc.subjectagkistrodotoxinen_US
dc.subjectMolecular replacementen_US
dc.subjectCalcium ionsen_US
dc.subjecthydrophobic interactionen_US
dc.subjectNeurotoxic siteen_US
dc.subjectphospholipase A2en_US
dc.subjectpresynaptic neurotoxinen_US
dc.titleStructure of Agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric uniten_US
dc.typeArticle
kusw.kuauthorTang, Liang
kusw.kudepartmentMolecular Biosciencesen_US
dc.identifier.doi10.1107/S0907444999012603
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record