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    Structure of Agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit

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    TangLiang_AC_1999(55)1986.pdf (1.141Mb)
    Issue Date
    1999-12-01
    Author
    Tang, Liang
    Zhou, Yuan-Cong
    Lin, Zheng-jiong
    Publisher
    International Union of Crystallography
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Metadata
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    Abstract
    The structure of agkistrodotoxin crystallized under basic conditions has been determined at 2.8 Å resolution by the molecular-replacement technique and refined to a crystallographic R factor of 0.194 and a free R factor of 0.260 with good stereochemistry. The molecular packing in the crystal differs from other PLA2s. The six molecules in the asymmetric unit form three dimers linked by Ca2+ ions in a near-perfect six-ligand octahedral coordinating system. Extensive intermolecular hydrophobic interactions occur at the interfacial recognition site of each neurotoxin molecule, which provides an insight into phospholipase A2-membrane interactions. This hydrophobic interaction-induced molecular association along the interfacial recognition site suggests a self-protection mechanism of agkistrodotoxin.
    Description
    This is the publisher's version, also available electronically from "http://scripts.iucr.org".
    URI
    http://hdl.handle.net/1808/17593
    DOI
    https://doi.org/10.1107/S0907444999012603
    Collections
    • Molecular Biosciences Scholarly Works [529]
    Citation
    Tang, L., Zhou, Y., & Lin, Z. (1999). Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit. Acta Crystallographica Section D Biological Crystallography, 55(12), 1986-1996. http://www.dx.doi.org/10.1107/S0907444999012603

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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