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Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch
dc.contributor.author | Marquez, Rebecca T. | |
dc.contributor.author | Xu, Liang | |
dc.date.accessioned | 2015-04-09T17:00:54Z | |
dc.date.available | 2015-04-09T17:00:54Z | |
dc.date.issued | 2012-02-28 | |
dc.identifier.citation | Marquez, Rebecca T. & Xu, Liang. "Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch." (2011) Am J Cancer Res. 2012; 2(2): 214–221. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/17365 | |
dc.description | This is the published version, also available here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304572/. | en_US |
dc.description.abstract | Cancer cells have developed novel mechanisms for evading chemotherapy-induced apoptosis and autophagy-associated cell death pathways. Upon the discovery that chemotherapeutics could target these cell death pathways in a manner that was not mutually exclusive, new discoveries about the interrelationship between these two pathways are emerging. Key proteins originally thought to be “autophagy-related proteins” are now found to be involved in either inducing or inhibiting apoptosis. Similarly, apoptosis inhibiting proteins can also block autophagy-associated cell death. One example is the complex formed by the autophagy protein, Beclin 1, and anti-apoptotic protein Bcl-2, which leads to inhibition of autophagy-associated cell death. Researchers have been investigating additional mechanisms that form/disrupt this complex in order to better design chemotherapeutics. This review will highlight the role Bcl-2 and Beclin 1 play in cancer development and drug resistance, as well as the role the Bcl-2:Beclin 1 complex in the switch between autophagy and apoptosis. | en_US |
dc.publisher | e-Century Publishing | en_US |
dc.relation.isversionof | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304572/ | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | autophagy | en_US |
dc.subject | Bcl-2 | en_US |
dc.subject | Beclin 1 | en_US |
dc.subject | Gossypol | en_US |
dc.subject | BH3 mimetics | en_US |
dc.title | Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch | en_US |
dc.type | Article | |
kusw.kuauthor | Xu, Liang | |
kusw.kudepartment | Molecular Biosciences | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |