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dc.contributor.authorMarquez, Rebecca T.
dc.contributor.authorXu, Liang
dc.date.accessioned2015-04-09T17:00:54Z
dc.date.available2015-04-09T17:00:54Z
dc.date.issued2012-02-28
dc.identifier.citationMarquez, Rebecca T. & Xu, Liang. "Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch." (2011) Am J Cancer Res. 2012; 2(2): 214–221.en_US
dc.identifier.urihttp://hdl.handle.net/1808/17365
dc.descriptionThis is the published version, also available here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304572/.en_US
dc.description.abstractCancer cells have developed novel mechanisms for evading chemotherapy-induced apoptosis and autophagy-associated cell death pathways. Upon the discovery that chemotherapeutics could target these cell death pathways in a manner that was not mutually exclusive, new discoveries about the interrelationship between these two pathways are emerging. Key proteins originally thought to be “autophagy-related proteins” are now found to be involved in either inducing or inhibiting apoptosis. Similarly, apoptosis inhibiting proteins can also block autophagy-associated cell death. One example is the complex formed by the autophagy protein, Beclin 1, and anti-apoptotic protein Bcl-2, which leads to inhibition of autophagy-associated cell death. Researchers have been investigating additional mechanisms that form/disrupt this complex in order to better design chemotherapeutics. This review will highlight the role Bcl-2 and Beclin 1 play in cancer development and drug resistance, as well as the role the Bcl-2:Beclin 1 complex in the switch between autophagy and apoptosis.en_US
dc.publishere-Century Publishingen_US
dc.relation.isversionofhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304572/en_US
dc.subjectApoptosisen_US
dc.subjectautophagyen_US
dc.subjectBcl-2en_US
dc.subjectBeclin 1en_US
dc.subjectGossypolen_US
dc.subjectBH3 mimeticsen_US
dc.titleBcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switchen_US
dc.typeArticle
kusw.kuauthorXu, Liang
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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