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Ultrastructural localization of the high molecular weight proteins associated with in vitro-assembled brain microtubules
dc.contributor.author | Dentler, William L., Jr | |
dc.contributor.author | Granett, Sandra | |
dc.contributor.author | Rosenbaum, Joel L. | |
dc.date.accessioned | 2015-03-09T19:50:26Z | |
dc.date.available | 2015-03-09T19:50:26Z | |
dc.date.issued | 1975-04-01 | |
dc.identifier.citation | Dentler, William L.; Granett, S.; Rosenbaum, J. L. (1975). "Ultrastructural localization of the high molecular weight proteins associated with in vitro-assembled brain microtubules." Journal of Cell Biology, 65(1):237-241. http://www.dx.doi.org/10.1083/jcb.65.1.237. | en_US |
dc.identifier.issn | 0021-9525 | |
dc.identifier.uri | http://hdl.handle.net/1808/17004 | |
dc.description | This is the publisher's version, also available electronically from http://jcb.rupress.org/content/65/1/237. | en_US |
dc.description.abstract | Microtubules isolated from brain extracts by in vitro assembly (1, 19, 23) are composed principally of two tubulins and two high molecular weight proteins (microtubule-associated proteins [MAPS] 1 and 2) (2,5,7,20). Recently, it was demonstrated that in vitro-assembled brain microtubules (neurotubules) are coated with filaments (5, 7) which are similar to the filaments attached to neurotubules in situ (4, 15, 21, 24, 25), and it was suggested that the filaments are composed of the higher molecular weight MAPs (5, 7, 12). In this study, microtubules were assembled in the presence and absence of the MAPs, and thin sections of the microtubules were examined by electron microscopy. The results show that the filaments only occur on microtubules assembled in the presence of the MAPs and it is therefore concluded that the filaments are composed of the high molecular weight MAP's. | en_US |
dc.publisher | Rockefeller University Press | en_US |
dc.title | Ultrastructural localization of the high molecular weight proteins associated with in vitro-assembled brain microtubules | en_US |
dc.type | Article | |
kusw.kuauthor | Dentler, William L., Jr | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1083/jcb.65.1.237 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |