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Structure of the Yersinia pestis tip protein LcrV refined to 1.65 A resolution
dc.contributor.author | Chaudhury, Sukanya | |
dc.contributor.author | Battaile, Kevin P. | |
dc.contributor.author | Lovell, Scott | |
dc.contributor.author | Plano, Gregory V. | |
dc.contributor.author | De Guzman, Roberto N. | |
dc.date.accessioned | 2015-03-09T17:44:34Z | |
dc.date.available | 2015-03-09T17:44:34Z | |
dc.date.issued | 2013-05-01 | |
dc.identifier.citation | Chaudhury, S.; Battaile, K. P.; Lovell, S.; Plano, G. V.; De Guzman, Roberto N. (2013). "Structure of the Yersinia pestis tip protein LcrV refined to 1.65 A resolution." Acta Crystallographica Section F., F69:477-481. http://www.dx.doi.org/10.1107/S1744309113008579. | en_US |
dc.identifier.issn | 1744-3091 | |
dc.identifier.uri | http://hdl.handle.net/1808/16998 | |
dc.description | This is the publisher's version, also available electronically from http://scripts.iucr.org/cgi-bin/paper?S1744309113008579. | en_US |
dc.description.abstract | The human pathogen Yersinia pestis requires the assembly of the type III secretion system (T3SS) for virulence. The structural component of the T3SS contains an external needle and a tip complex, which is formed by LcrV in Y. pestis. The structure of an LcrV triple mutant (K40A/D41A/K42A) in a C273S background has previously been reported to 2.2 Å resolution. Here, the crystal structure of LcrV without the triple mutation in a C273S background is reported at a higher resolution of 1.65 Å. Overall the two structures are similar, but there are also notable differences, particularly near the site of the triple mutation. The refined structure revealed a slight shift in the backbone positions of residues Gly28-Asn43 and displayed electron density in the loop region consisting of residues Ile46-Val63, which was disordered in the original structure. In addition, the helical turn region spanning residues Tyr77-Gln95 adopts a different orientation. | en_US |
dc.publisher | International Union of Crystallography | en_US |
dc.title | Structure of the Yersinia pestis tip protein LcrV refined to 1.65 A resolution | en_US |
dc.type | Article | |
kusw.kuauthor | De Guzman, Roberto N. | |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1107/S1744309113008579 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |