dc.contributor.author | Ackley, Brian D. | |
dc.contributor.author | Crew, Jennifer R. | |
dc.contributor.author | Elamaa, Harri | |
dc.contributor.author | Pihlajaniemi, Tania | |
dc.contributor.author | Kuo, Calvin J. | |
dc.contributor.author | Kramer, James M. | |
dc.date.accessioned | 2014-10-06T18:09:59Z | |
dc.date.available | 2014-10-06T18:09:59Z | |
dc.date.issued | 2001-03-19 | |
dc.identifier.citation | Ackley, B.D.; Crew, J.R.; Elamaa, H.; Pihlajaniemi, T.; Kuo, C.J.; Kramer, J.M. (2001). "The NC1/Endostatin Domain of
Caenorhabditis elegans Type XVIII Collagen Affects Cell Migration and Axon Guidance." Journal of Cellular Biology, 152(6):1219. http://www.dx.doi.org/10.1083/jcb.152.6.1219. | |
dc.identifier.issn | 0021-9525 | |
dc.identifier.uri | http://hdl.handle.net/1808/15182 | |
dc.description | This is the publisher's version, also available electronically from http://jcb.rupress.org/content/152/6/1219. | |
dc.description.abstract | Type XVIII collagen is a homotrimeric basement membrane molecule of unknown function, whose COOH-terminal NC1 domain contains endostatin (ES), a potent antiangiogenic agent. The Caenorhabditis elegans collagen XVIII homologue, cle-1, encodes three developmentally regulated protein isoforms expressed predominantly in neurons. The CLE-1 protein is found in low amounts in all basement membranes but accumulates at high levels in the nervous system. Deletion of the cle-1 NC1 domain results in viable fertile animals that display multiple cell migration and axon guidance defects. Particular defects can be rescued by ectopic expression of the NC1 domain, which is shown to be capable of forming trimers. In contrast, expression of monomeric ES does not rescue but dominantly causes cell and axon migration defects that phenocopy the NC1 deletion, suggesting that ES inhibits the promigratory activity of the NC1 domain. These results indicate that the cle-1 NC1/ES domain regulates cell and axon migrations in C. elegans. | |
dc.publisher | The Rockefeller University Press | |
dc.subject | Cell migration | |
dc.subject | Neurogenesis | |
dc.subject | endostatin | |
dc.subject | Collagen | |
dc.subject | Caenorhabditis elegans | |
dc.title | The NC1/Endostatin Domain of Caenorhabditis elegans Type XVIII Collagen Affects Cell Migration and Axon Guidance | |
dc.type | Article | |
kusw.kuauthor | Ackley, Brian D. | |
kusw.kudepartment | Molecular Biosciences | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1083/jcb.152.6.1219 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess | |