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Oligomerization-dependent Regulation of Motility and Morphogenesis by the Collagen XVIII NC1/Endostatin Domain
dc.contributor.author | Kuo, Calvin J. | |
dc.contributor.author | LaMontagne, Kenneth R. | |
dc.contributor.author | Garcia-Cardeña, Guillermo | |
dc.contributor.author | Ackley, Brian D. | |
dc.contributor.author | Kalman, Daniel | |
dc.contributor.author | Park, Susan | |
dc.contributor.author | Christofferson, Rolf | |
dc.contributor.author | Kamihara, Junne | |
dc.contributor.author | Ding, Yuan-Hua | |
dc.contributor.author | Lo, Kin-Ming | |
dc.contributor.author | Gillies, Stephen | |
dc.contributor.author | Folkman, Judah | |
dc.contributor.author | Mulligan, Richard C. | |
dc.contributor.author | Javaherian, Kashi | |
dc.date.accessioned | 2014-10-06T15:41:51Z | |
dc.date.available | 2014-10-06T15:41:51Z | |
dc.date.issued | 2001-03-19 | |
dc.identifier.citation | Kuo, Calvin J. 2001. "Oligomerization-dependent Regulation of Motility and Morphogenesis by the Collagen XVIII NC1/Endostatin Domain." Journal of Cell Biology, v. 1152, pp. 1233. http://www.dx.doi.org/10.1083/jcb.152.6.1233 | |
dc.identifier.issn | 0021-9525 | |
dc.identifier.uri | http://hdl.handle.net/1808/15178 | |
dc.description | This is the publisher's version, also available electronically from http://jcb.rupress.org/content/152/6/1233. | |
dc.description.abstract | Collagen XVIII (c18) is a triple helical endothelial/epithelial basement membrane protein whose noncollagenous (NC)1 region trimerizes a COOH-terminal endostatin (ES) domain conserved in vertebrates, Caenorhabditis elegans and Drosophila. Here, the c18 NC1 domain functioned as a motility-inducing factor regulating the extracellular matrix (ECM)-dependent morphogenesis of endothelial and other cell types. This motogenic activity required ES domain oligomerization, was dependent on rac, cdc42, and mitogen-activated protein kinase, and exhibited functional distinction from the archetypal motogenic scatter factors hepatocyte growth factor and macrophage stimulatory protein. The motility-inducing and mitogen-activated protein kinase–stimulating activities of c18 NC1 were blocked by its physiologic cleavage product ES monomer, consistent with a proteolysis-dependent negative feedback mechanism. These data indicate that the collagen XVIII NC1 region encodes a motogen strictly requiring ES domain oligomerization and suggest a previously unsuspected mechanism for ECM regulation of motility and morphogenesis. | |
dc.publisher | The Rockefeller University Press | |
dc.subject | Collagen XVIII | |
dc.subject | endostatin | |
dc.subject | Motility | |
dc.subject | Morphogenesis | |
dc.subject | Extracellular matrix | |
dc.title | Oligomerization-dependent Regulation of Motility and Morphogenesis by the Collagen XVIII NC1/Endostatin Domain | |
dc.type | Article | |
kusw.kuauthor | Ackley, Brian D. | |
kusw.kudepartment | Molecular Biosciences | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1083/jcb.152.6.1233 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |