ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Pharmacy Dissertations and Theses: Recent submissions
Now showing items 81-100 of 118
-
Pharmacological Induction of Molecular Chaperones Restores Mitochondrial Function in Hyperglycemically Stressed Sensory Neurons
(University of Kansas, 2012-12-31)Distal diabetic peripheral polyneuropathy (DPN) is a prevalent complication resulting from chronic hyperglycemia in diabetic patients. It is associated with incapacitating pain, foot ulceration, and lower-limb amputations ... -
Role of Coagulation in Xenobiotic-Induced Liver Injury
(University of Kansas, 2012-08-31)The liver is a common target for xenobiotic-induced toxicity. Of importance, synthesis of soluble coagulation factors by the liver plays an essential role in hemostasis. Blood coagulation cascade activation is evident in ... -
Role of Interleukin-1beta and neutrophil activation during acetaminophen overdose
(University of Kansas, 2012-08-31)Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US. APAP is metabolized to a reactive metabolite that causes hepatotoxicity in a dose-dependent manner. A series of cascading intracellular ... -
THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
(University of Kansas, 2012-08-31)Redox maintenance is critical for all biological species. Amplification of mechanisms that reduces oxidative/electrophilic stress promotes health and extends life. Nuclear factor, erythroid derived 2, like 2 (Nrf2) is a ... -
Neuronal Protection by a Novel C-terminal Hsp90 Modulator
(University of Kansas, 2012-08-31)Alzheimer's disease (AD), like most neurodegenerative disorders, is characterized by accumulation of misfolded and aggregated proteins, indicating that the protein quality control machinery is compromised. Enhancing the ... -
Effects of the Over-Expression of Neuronal Glutamate Dehydrogenase (Glud1) on Mouse Brain Mitochondrial Function
(University of Kansas, 2012-08-31)Glutamate has been shown to lead to neurotoxicity and subsequent neurodegeneration through changes in synaptic function, loss of glutamatergic neurons, synapses, and dendrites. All of these characteristics are also observed ... -
Intracellular drug distribution-based targeting: Exploiting lysosomes to enhance the selectivity of drugs towards cancer cells
(University of Kansas, 2012-08-31)Under the most ideal circumstances, anticancer agents should be minimally toxic to normal cells and maximally noxious to cancer cells. Unfortunately, an optimal degree of selectivity is not typically achieved and chemotherapy ... -
Investigating the Aggregation of the Basic Leucine Zipper (bZIP) Domain of Activating Transcription Factor 5 (ATF5)
(University of Kansas, 2010-05-31)Protein aggregation is a major problem for biopharmaceuticals. Aggregate formation in a drug formulation can have serious health implications for the patient. While the control of protein aggregation is critically important ... -
FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS
(University of Kansas, 2011-12-31)Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs ... -
Substrate Dependent Alterations of Organic Anion Transporting Polypeptide 1B3 (OATP1B3)
(University of Kansas, 2011-12-31)Organic anion transporting polypeptides (OATPs) are multispecific transporters that mediate the uptake of numerous drugs and xenobiotics into cells. Alterations in the function of the liver–specific OATP1B1 and OATP1B3 ... -
REGULATION OF DRUG METABOLISM AND INFLAMMATION BY PREGNANE X RECEPTOR
(University of Kansas, 2011-12-31)Liver-enriched nuclear receptor (NR) proteins regulate the expression and activity of several pivotal hepatic biochemical pathways including the uptake, metabolism and excretion of cholesterol, bile acids, glucose, and ... -
THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
(University of Kansas, 2011-08-31)Farnesoid X receptor (FXR) is a ligand activated transcription factor belonging to the nuclear receptor superfamily and bile acids are its endogenous ligands. FXR is a critical regulator of the enterohepatic circulation ... -
CHARACTERIZATION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A1 (OATP1A1) IN THE BILE ACID HOMEOSTASIS OF MICE
(University of Kansas, 2011-04-20)Organic anion transporting polypeptides (human: OATPs; all other species: Oatps; gene symbol: SLCO/Slco) are sodium-independent transport systems that mediate the transmembrane transport of a wide range of amphipathic ... -
SEX STEROIDS MODULATE NOCICEPTION, AND ESTROGEN MODIFIES SUPRASPINAL NOCICEPTIVE ACTIVATION
(University of Kansas, 2010-12-10)Chronic pain leads neurological disorders in the US both in terms of numbers of cases and economic cost. The understanding of sex differences in the sensory experience of pain is emerging. For example, the incidence of ... -
NEW APPROACHES IN UNDERSTANDING DRUG METABOLISM
(University of Kansas, 2011-02-22)Limitations in technology, such as DNA sequencing and appropriate model systems, have made it difficult to understand the genetic and non-genetic factors that influence the liver's role in metabolizing drugs. New approaches ... -
Mechanisms of Proinflammatory Signaling during Cholestasis
(University of Kansas, 2011-04-11)Cholestasis is a condition in which bile flow from the liver to the intestines is inhibited. Loss of bile flow leads to increased concentrations of bile constituents, including bilirubin and bile acids within the liver. ... -
EFFECT OF BILE ACID FEEDING AND SEQUESTRATION ON LIVER BILE ACID COMPOSITION AND GENE REGULATION IN MICE
(University of Kansas, 2010-12-16)The dissertation investigates the non-hepatotoxic doses of five bile acids (BAs) in the feed of mice, as well as adaptations in the expression of genes involved in BA homeostasis and the possible roles of FXR-mediated ... -
Molecular Mechanism of Polybrominated Diphenyl Ether Disposition in the Liver
(University of Kansas, 2010-10-01)Polybrominated diphenyl ethers (PBDEs) were introduced in the late 1970's as additive flame retardants incorporated into textiles, electronics, plastics and furniture. Although 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ... -
Computational Molecular Modeling Studies of the Interactions of Estrogens with Their Receptors and Intracellular Estrogen Binding Protein PDIp
(University of Kansas, 2010-09-27)The endogenous estrogens are vitally-important female sex hormones with diverse biological functions. Disruption of their actions contributes to the pathogenesis of a number of disease states in humans, such as endocrine ... -
STRUCTURAL REQUIREMENTS OF ORGANIC ANION TRANSPORTING POLYPEPTIDE MEDIATED TRANSPORT
(University of Kansas, 2010-04-12)The organic anion transporting polypeptides (human: OATP; other: Oatp) form a mammalian transporter superfamily that mediates the transport of structurally unrelated compounds across the cell membrane. Members in this ...