Protein Function Assignment through Mining Cross-Species Protein-Protein Interactions
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Fang, Jianwen; Haasl, R. J.; Dong, Yinghua; Lushington, Gerald H. (BIOMED CENTRAL LTD, 2005-11-23)Background: The development of high-throughput technologies such as yeast two- hybrid systems and mass spectrometry technologies has made it possible to generate large protein-protein interaction ( PPI) datasets. Mining ...
Development of Novel Fluorescence and NMR Reagents for Monitoring Protein-Protein Interactions Between Survivin and Its Protein Binding Partners Bishop, Stephanie Cara (University of Kansas, 2015-08-31)Inhibition of protein-protein interactions is a promising therapeutic strategy for targeting non-enzymatic proteins. One strategy to inhibit protein-protein interactions is to design inhibitors specifically toward the ...
Druggable Protein Interaction Sites Are More Predisposed to Surface Pocket Formation than the Rest of the Protein Surface Johnson, David K.; Karanicolas, John (Public Library of Science, 2013-03-07)Despite intense interest and considerable effort via high-throughput screening, there are few examples of small molecules that directly inhibit protein-protein interactions. This suggests that many protein interaction ...