Chemistry Scholarly Works: Recent submissions
Now showing items 221-240 of 629
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Structural Studies of Bacterioferritin B (BfrB) from Pseudomonas aeruginosa Suggest a Gating Mechanism for Iron Uptake via the Ferroxidase Center
(ACS, 2010-02-16)The structure of recombinant P. aeruginosa bacterioferritin B (Pa BfrB) has been solved from crystals grown from protein devoid of core mineral iron (as-isolated) and from protein mineralized with ~ 600 iron atoms ... -
Kinetic and Structural Analysis of Substrate Specificity in Two Copper Amine Oxidases from Hansenula polymorpha
(ACS, 2010-03-23)The structural underpinnings of enzyme substrate specificity are investigated in a pair of copper amine oxidases (CAOs) from Hansenula polymorpha (HPAO-1 and HPAO-2). The X-ray crystal structure (to 2.0 Å resolution) and ... -
Kinetic and spectroscopic studies of hemin acquisition in the hemophore HasAp from Pseudomonas aeruginosa
(ACS, 2010-08-10)The extreme limitation of free iron has driven various pathogens to acquire iron from the host in the form of heme. Specifically, several Gram negative pathogens secrete a heme binding protein known as HasA to scavenge ... -
Crystal Structure of Prolyl 4-Hydroxylase from Bacillus anthracis
(ACS, 2010-01-12)Prolyl 4-hydroxylases (P4H) catalyze the posttranslational hydroxylation of proline residues and play a role in collagen production, hypoxia response, and cell wall development. P4Hs belong to the Fe(II)/αKG oxygenases and ... -
Stereochemically Probing the photo-favorskii Rearrangement: A Mechanistic Investigation
(American Chemical Society, 2013-03-01)Using model (R)-2-acetyl-2-phenyl acetate esters of (S)- or (R)-α-substituted-p-hydroxybutyrophenones (S,R)-12a and (R,R)-12b, we have shown that a highly efficient photo-Favorskii rearrangement proceeds through a series ... -
Binding of Pseudomonas aeruginosa Apo-Bacterioferritin Associated Ferredoxin to Bacterioferritin B Promotes Heme Mediation of Electron Delivery and Mobilization of Core Mineral Iron†
(ACS, 2009-08-11)The bfrB gene from Pseudomonas aeruginosa was cloned and expressed in E. coli. The resultant protein (BfrB), which assembles into a 445.3 kDa complex0020from 24 identical subunits, binds 12 molecules of heme axially ... -
Skeletal Diversification via Heteroatom Linkage Control: Preparation of Bicyclic and Spirocyclic Scaffolds from NSubstituted Homopropargyl Alcohols
(American Chemical Society, 2013-04-13)The discovery and application of a new branching pathway synthesis strategy that rapidly produces skeletally diverse scaffolds is described. Two different scaffold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary ... -
Silica-Supported Oligomeric Benzyl Phosphate (Si-OBP) and Triazole Phosphate (Si-OTP) Alkylating Reagents
(American Chemical Society, 2015-10-16)The syntheses of silica-supported oligomeric benzyl phosphates (Si-OBPn) and triazole phosphates (Si-OTPn) using ring-opening metathesis polymerization (ROMP) for use as efficient alkylating reagents is reported. Ease of ... -
Phosphate Tether-Mediated Approach to the Formal Total Synthesis of (-)-Salicylihalamides A and B
(American Chemical Society, 2011-05-20)A concise formal synthesis of the cytotoxic macrolides (-)-salicylihalamides A and B is reported. Key features of the synthetic strategy include a chemoselective hydroboration, highly regio- and diastereoselective methyl ... -
Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters
(American Chemical Society, 2009-06-19)Herein we report that simple Lewis acids catalyze the hydroarylation of benzylidene malonates with phenols. Ultimately, 3,4-disubstituted dihydrocoumarins are obtained via a hydroarylation-lactonization sequence. Moreover, ... -
Gas-phase Fragmentation of Deprotonated p-Hydroxyphenacyl Derivatives
(American Chemical Society, 2011-04-01)Electrospray ionization of methanolic solutions of p-hydroxyphenacyl derivatives HO-C6H4-C(O)-CH2-X (X = leaving group) provides abundant signals for the deprotonated species which are assigned to the corresponding phenolate ... -
Development of Asymmetic Deacylative Allylation
(American Chemical Society, 2013-07-19)Herein we present the development of asymmetric deacylative allylation of ketone enolates. The reaction directly couples readily available ketone pronucleophiles with allylic alcohols using facile retro-Claisen cleavage ... -
Synthetic Studies to Lyngbouilloside: A Phosphate Tether-Mediated Synthesis of the Macrolactone Core
(Elsevier, 2015-06-03)A concise synthetic pathway to the originally assigned structure of lyngbouilloside macrolactone (3) is reported. The core macrocycle 3 was synthesized via a phosphate tether-mediated, one-pot, sequential RCM/CM/chemoselective ... -
Optimism and Physical Health: A Meta-analytic Review
(Springer Verlag, 2009-06)Background—Prior research links optimism to physical health, but the strength of the association has not been systematically evaluated. Purpose—The purpose of this study is to conduct a meta-analytic review to determine ... -
Deacylative allylation of nitroalkanes: unsymmetric bisallylation via 3-component coupling
(Wiley, 2011-02-11)Use it and lose it! Allylic alcohols were used directly for the synthesis of diallylated nitroalkanes in a three-component coupling based on the strategy of deacylative allylation for the in situ generation of a nucleophile ... -
1,3-Allylic Strain as a Strategic Diversification Element For Constructing Libraries of Substituted 2-Arylpiperidines
(Wiley, 2011-03-14)Flipping diversity—Minimization of 1,3-allylic strain is a recurring element in the design of a stereochemically- and spatially-diverse collection of 2-arylpiperidines. Here, stereochemicallydiverse scaffolding is first ... -
Separation and Detection of Peroxynitrite Using Microchip Electrophoresis with Amperometric Detection
(American Chemical Society, 2010-03-01)Peroxynitrite (ONOO-) is a highly reactive species implicated in the pathology of several cardiovascular and neurodegenerative diseases. It is generated in vivo by the diffusion-limited reaction of nitric oxide (NO•) and ... -
GlycoPep Grader: A web-based utility for assigning the composition of N-linked glycopeptides
(American Chemical Society, 2012-06-05)GlycoPep Grader (GPG) is a freely-available software tool designed to accelerate the process of accurately determining glycopeptide composition from tandem mass spectrometric data. GPG relies on the identification of unique ... -
GlycoPep Detector: A tool for assigning mass spectrometry data of N-linked glycopeptides based on their ETD spectra
(American Chemical Society, 2013-05-21)Electron transfer dissociation (ETD) is commonly used in fragmenting N-linked glycopeptides in their mass spectral analyses to complement collision induced dissociation (CID) experiments. The glycan remains intact through ... -
Characterizing O-linked glycopeptides by electron transfer dissociation: fragmentation rules and applications in data analysis
(American Chemical Society, 2013-08-22)Studying protein O-glycosylation remains an analytical challenge. Different from N-linked glycans, the O-glycosylation site is not within a known consensus sequence. Additionally, O-glycans are heterogeneous with numerous ...