Pharmacy, School of: Recent submissions
Now showing items 81-100 of 417
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Clusterin in the Brain
(University of Kansas, 2017-12-31)Late-onset Alzheimer’s disease (LOAD) is an age-related chronic neurodegenerative disorder traditionally characterized by the presence of neurotoxic amyloid beta (Aβ) plaques, neurofibrillary tangles, and progressive, ... -
Targeting Heat Shock Protein 70 to Improve Oxidative Stress and Mitochondrial Bioenergetics in Diabetic Sensory Neurons
(University of Kansas, 2017-12-17)Neuronal mitochondrial dysfunction is a key pathophysiologic mechanism of diabetic peripheral neuropathy (DPN). KU-596 is a small molecule modulator of heat shock protein 90 (Hsp90) that can reverse clinically relevant ... -
CHARACTERIZATION OF MOLECULAR AND GENETIC DETERMINANTS OF POLY (ADP-RIBOSE) POLYMERASE INHIBITOR SENSITIVITY IN OVARIAN CANCER
(University of Kansas, 2018-05-31)Ovarian cancer is the most leathal cancer among gynecologic cancers in the United States and is the fifth leading cause of cancer death among American women. Approximately sixty percent of women with ovarian cancer are ... -
Targeting vulnerabilities through inhibiting the valosin-containing protein (VCP/p97) in ovarian cancer
(University of Kansas, 2018-05-31)Ovarian cancer is the fifth leading cause of cancer-related death among women and the deadliest of all gynecological cancers. Treatment failure is a major contributing factor in ovarian cancer-related mortality. Advances ... -
IDENTIFICATION AND CHARACTERIZATION OF THE OLIGOMERIZATION AND STRUCTURAL FUNCTIONAL RELATIONSHIP OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B3
(University of Kansas, 2017-12-31)Many transporters are expressed at the basolateral membrane of human hepatocytes, including Organic Anion Transporting Polypeptide 1B1 (OATP1B1), OATP1B3, Organic Cation Transporter 1 (OCT1), Na+/Taurocholate Cotransporting ... -
Creating an Online Interprofessional Collaborative Team Simulation to Overcome Common Barriers of Interprofessional Education
(De Gruyter Open, 2017-09-15)Introduction: Coordinating student schedules, physical space, and faculty time are commonly reported barriers to successful interprofessional education. Use of online technologies to overcome these barriers and support ... -
Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia
(Frontiers Media, 2017-05-17)Hypoxia inducible factor-1 (HIF-1) is a key regulator in hypoxia and can determine the fate of brain cells during ischemia. However, the mechanism of HIF-1 regulation is still not fully understood in ischemic brains. We ... -
IDENTIFICATION OF ENDOGENOUS FUNCTION AND SUBSTRATE-DEPENDENT INTERACTIONS OF ORGANIC CATION TRANSPORTER 1
(University of Kansas, 2018-05-31)The human organic cation transporter 1 (hOCT1) is a polyspecific transporter, primarily expressed in the liver, which is known to interact with a large number of structurally dissimilar compounds. Several clinically-relevant ... -
Effect of Continuous and Sequential Therapy among Veterans Receiving Daptomycin or Linezolid for Vancomycin-Resistant Enterococcus faecium Bacteremia
(American Society for Microbiology, 2017)Vancomycin-resistant Enterococcus faecium bloodstream infections (VREF-BSI) cause significant mortality, highlighting the need to optimize their treatment. We compared the effectiveness and safety of daptomycin (DAP) and ... -
ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
(University of Kansas, 2017-12-31)Acetaminophen (APAP) overdose is a leading cause of acute liver failure (ALF) with limited treatment options. The mechanisms of APAP-induced liver injury include formation of a reactive metabolite N-acetyl-p-quinoneimine ... -
Mechanistic Biomarkers in Acute Liver Injury
(University of Kansas, 2017-12-31)Acute liver failure continues to be a major medical problem. There are many underlying causes of acute liver failure, but drug induced liver injury is the most common. However, ischemic injury secondary to either liver ... -
The Role of O-GlcNAc in Liver Injury and Regeneration
(University of Kansas, 2017-12-31)O-GlcNAcylation is a covalent attachment of a single N-acetyl glucosamine to a serine or threonine residue of a protein. Unlike other forms of protein glycosylation, there is no chain elongation in O-GlcNAcylation. O-GlcNAc ... -
HEPATIC WOUND HEALING FOLLOWING ACUTE AND CHRONIC LIVER INJURY: A POTENTIAL ROLE FOR THE HYALURONAN NETWORK
(University of Kansas, 2017-08-31)Chronic liver disease is the 12th leading cause of death in the United States and consists of a continuum of pathologies. Following initial injury, a patient develops steatosis, or excess fat accumulation. While the liver ... -
MITOCHONDRIAL OXIDATIVE STRESS AND BIOGENESIS DURING ACETAMINOPHEN HEPATOTOXICITY
(University of Kansas, 2017-05-31)Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans. Although numerous studies have established the existence of an extensive oxidative stress during APAP hepatotoxicity, its source, ... -
Use of Task-Relevant Spoken Word Stimuli in an Auditory Brain-Computer Interface
(University of Kansas, 2017-05-31)Auditory brain-computer interfaces (aBCI) may be an effective solution for communication in cases of severely locked-in, late stage ALS (Lou Gehrig’s disease) and upper spinal cord injury patients who are otherwise not ... -
Characterization of a Novel Tau Aggregation Inhibitor Isolated from Fungal Secondary Metabolites
(University of Kansas, 2017-05-31)Alzheimer’s disease is the 6th leading cause of death in the U.S. and the cost of care is billions of dollars per year. Tau aggregation is a pathological hallmark in neurodegenerative diseases known as tauopathies, which ... -
New insights and changing paradigms in the regulation of vitamin A metabolism in development
(Wiley, 2017-05)Vitamin A and its active metabolite retinoic acid are essential for embryonic development and adult homeostasis. Surprisingly, excess or deficiency of vitamin A and retinoic acid can cause similar developmental defects. ... -
Human ApoE ε2 promotes regulatory mechanisms of bioenergetic and synaptic function in female brain: a focus on V-type H+-ATPase
(IOS Press, 2016-08-03)Humans possess three major isoforms of the apolipoprotein E (ApoE) gene encoded by three alleles: ApoE ε2 (ApoE2), ApoE ε3 (ApoE3), and ApoE ε4 (ApoE4). It is established that the three ApoE isoforms confer differential ... -
Aversive properties of negative incentive shifts in Fischer 344 and Lewis rats
(Elsevier, 2017-02-15)Research on incentive contrast highlights that reward value is not absolute but rather is based upon comparisons we make to rewards we have received and expect to receive. Both human and nonhuman studies on incentive ... -
PXR IN BRAIN: NOVEL METHODS TO CHARACTERIZE ITS BIOLOGY
(University of Kansas, 2017-05-31)Pregnane X receptor (PXR, NR1I2) belongs to the nuclear receptor superfamily of ligand-activated transcription factors and was identified in 1998. PXR is highly expressed in the liver and intestine, and is involved in ...